Research map: Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing

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Papers in this map

  1. Drug repurposing: progress, challenges and recommendations · Sudeep P. Pushpakom · 2018 · 4872 citations · Cited by this paper
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  15. Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors · François Doz · 2021 · 179 citations · Cited by this paper
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  19. β-catenin-mediated YAP signaling promotes human glioma growth · Yan Wang · 2017 · 89 citations · Cited by this paper
  20. α6GABAA receptor-selective positive allosteric modulator as a novel therapy for fibromyalgia: A proof-of-concept study in mice modeling chronic widespread musculoskeletal pain · 2026 · Related
  21. The Role of De Novo Noncoding Regulatory Mutations in Neurodevelopmental Disorders · Tychele N. Turner · 2018 · 78 citations · Cited by this paper
  22. Bevacizumab for radiation necrosis following radiotherapy of brain metastatic disease: a systematic review & meta-analysis · Muhammad Babar Khan · 2021 · 78 citations · Cited by this paper
  23. Insights into Computational Drug Repurposing for Neurodegenerative Disease · Manish D. Paranjpe · 2019 · 76 citations · Cited by this paper
  24. Splicing and neurodegeneration: Insights and mechanisms · Sara Nik · 2019 · 68 citations · Cited by this paper
  25. YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial · Timothy Anthony Yap · 2025 · 61 citations · Cited by this paper
  26. Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System · Nithya Srinivas · 2018 · 49 citations · Cited by this paper
  27. Drug repurposing in neurological diseases: an integrated approach to reduce trial and error · Alexander E. Clout · 2019 · 47 citations · Cited by this paper
  28. Bevacizumab combined with chemotherapy vs single-agent therapy in recurrent glioblastoma: evidence from randomized controlled trials · Zhouqing Chen · 2018 · 24 citations · Cited by this paper
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