Research map: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

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  1. Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction · Jeong‐a Kim · 2006 · 1654 citations · Cited by this paper
  2. 1314-OR: Allogeneic Islets Are Rejected by Diabetic NOD Mice while Allogeneic Neo-Islets, 3D Organoids of Islet and Mesenchymal Stromal Cells, Durably Cure Their Type 1 Diabetes without Antirejection Drugs: Mechanisms · 2026 · Related
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  11. Diabetic Microvascular Disease: An Endocrine Society Scientific Statement · Eugene J. Barrett · 2017 · 522 citations · Cited by this paper
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  13. Microvascular Recruitment Is an Early Insulin Effect That Regulates Skeletal Muscle Glucose Uptake In Vivo · Michelle A. Keske · 2004 · 440 citations · Cited by this paper
  14. Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles · 2026 · Related
  15. Blood flow and muscle metabolism: a focus on insulin action · Michael G. Clark · 2003 · 359 citations · Cited by this paper
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  17. Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells · Monica Montagnani · 2002 · 331 citations · Cited by this paper
  18. Effects of Pharmacological GIP Infusion on Insulin, Glucagon, and Cardiovascular Responses During Hyperglycemia in Type 2 Diabetes · 2026 · Related
  19. Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries. · Yasuaki Dohi · 1992 · 269 citations · Cited by this paper
  20. The expanding incretin universe: from basic biology to clinical translation · Daniel J. Drucker · 2023 · 241 citations · Cited by this paper
  21. Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats · Francis Christopher Lynn · 2001 · 209 citations · Cited by this paper
  22. Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism · Weidong Chai · 2012 · 194 citations · Cited by this paper
  23. Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature · Eugene J. Barrett · 2011 · 173 citations · Cited by this paper
  24. Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo · Lucy H. Clerk · 2002 · 159 citations · Cited by this paper
  25. GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene · Su‐jin Kim · 2010 · 134 citations · Cited by this paper
  26. The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake · Lucy H. Clerk · 2003 · 105 citations · Cited by this paper
  27. GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans · Sharmila C. Subaran · 2014 · 96 citations · Cited by this paper
  28. The endothelial cell: An “early responder” in the development of insulin resistance · Eugene J. Barrett · 2013 · 90 citations · Cited by this paper
  29. Angiotensin II Type 1 and Type 2 Receptors Regulate Basal Skeletal Muscle Microvascular Volume and Glucose Use · Weidong Chai · 2009 · 89 citations · Cited by this paper
  30. Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiogensin-converting enzyme inhibition · Lucy H. Clerk · 2007 · 87 citations · Cited by this paper
  31. MEF2 (Myocyte Enhancer Factor 2) Is Essential for Endothelial Homeostasis and the Atheroprotective Gene Expression Program · Yao Wei Lu · 2021 · 77 citations · Cited by this paper
  32. The influence of Glucose-dependent Insulinotropic Polypeptide (GIP) on human adipose tissue and fat metabolism: Implications for obesity, type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD) · Sravan Kumar Thondam · 2019 · 76 citations · Cited by this paper
  33. The Potential Beneficial Role of Glucagon-like Peptide-1 in Endothelial Dysfunction and Heart Failure Associated with Insulin Resistance · Thomas Nyström · 2008 · 75 citations · Cited by this paper
  34. Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin’s Metabolic Action in the Presence of Insulin Resistance · Weidong Chai · 2014 · 73 citations · Cited by this paper
  35. Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance · Nasui Wang · 2019 · 73 citations · Cited by this paper
  36. Protein kinase A mediates glucagon-like peptide 1-induced nitric oxide production and muscle microvascular recruitment · Zhenhua Dong · 2012 · 71 citations · Cited by this paper
  37. Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo · Weidong Chai · 2011 · 70 citations · Cited by this paper
  38. Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells · Qing Zhong · 2000 · 69 citations · Cited by this paper
  39. Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB · Lisa M. Berglund · 2015 · 65 citations · Cited by this paper

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