Research map: NEKfla: A Genetically Encoded Förster Resonance Energy Transfer Biosensor for Live-Cell Monitoring of Early NIMA-related kinase 7–NLR family pyrin domain containing 3 Inflammasome Signaling

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  1. The NLRP3 inflammasome: molecular activation and regulation to therapeutics · Karen V. Swanson · 2019 · 4883 citations · Cited by this paper
  2. A Dual-Mechanism Targeted Cross-Convergence Prodrug Activation Strategy Enabled by Biological Stimulus Amplification toward Precision Cancer Therapy · 2026 · Related
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  9. K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter · Raúl Muñoz-Planillo · 2013 · 2204 citations · Cited by this paper
  10. Ultrasound-Activated Nanoplatform Counteracts Triple-Negative Breast Cancer via Remodeling Intratumoral Microbiota–Metabolism and Inducing Ferroptosis · 2026 · Related
  11. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf · Sanjeev Mariathasan · 2004 · 1854 citations · Cited by this paper
  12. Innovative Hydrogel Technologies: Advancing Bone Regeneration with Novel Techniques · 2026 · Related
  13. NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder · Laetitia Agostini · 2004 · 1772 citations · Cited by this paper
  14. A Tumor-Responsive Enzymatic Cascade System Inducing pH-Activable Metabolic Starvation and H 2 O 2 -Induced Apoptosis · 2026 · Related
  15. NLRP3 inflammasome activation drives tau pathology · Christina Ising · 2019 · 1587 citations · Cited by this paper
  16. A Glucose-Responsive Hydrogel with Multifunctional Properties for Accelerated Diabetic Wound Healing · 2026 · Related
  17. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux · Yuan He · 2016 · 1316 citations · Cited by this paper
  18. Light-Curable Methacrylated Carboxymethyl Chitosan Hydrogel Incorporating Bone Morphogenic Protein-2-Immobilized Bioactive Glass for Spinal Bone Regeneration · 2026 · Related
  19. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation · Teresa Fernandes‐Alnemri · 2007 · 1046 citations · Cited by this paper
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  21. Critical role for calcium mobilization in activation of the NLRP3 inflammasome · Tomohiko Murakami · 2012 · 935 citations · Cited by this paper
  22. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome · Humayun Sharif · 2019 · 839 citations · Cited by this paper
  23. Human Monocytes Engage an Alternative Inflammasome Pathway · Moritz M. Gaidt · 2016 · 802 citations · Cited by this paper
  24. NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease · Grace Chen · 2008 · 770 citations · Cited by this paper
  25. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component · Hexin Shi · 2015 · 762 citations · Cited by this paper
  26. Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis · Zhu Chen · 2018 · 739 citations · Cited by this paper
  27. Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation · Benjamin Faustin · 2007 · 713 citations · Cited by this paper
  28. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3 · Moritz M. Gaidt · 2017 · 660 citations · Cited by this paper
  29. Pyroptosis · Lieselotte Vande Walle · 2016 · 645 citations · Cited by this paper
  30. Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis · Susanne Gaul · 2020 · 563 citations · Cited by this paper
  31. Inflammasome activation in infected macrophages drives COVID-19 pathology · Esen Sefik · 2022 · 549 citations · Cited by this paper
  32. MCC950 closes the active conformation of NLRP3 to an inactive state · Ana Tapia‐Abellán · 2019 · 454 citations · Cited by this paper
  33. Cell Volume Regulation Modulates NLRP3 Inflammasome Activation · Vincent Compan · 2012 · 408 citations · Cited by this paper
  34. The role of inflammasomes in human diseases and their potential as therapeutic targets · Jing Yao · 2024 · 248 citations · Cited by this paper
  35. Roles for RACK1 in cancer cell migration and invasion · Deirdre Duff · 2017 · 201 citations · Cited by this paper
  36. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly · Florian Ingo Schmidt · 2016 · 191 citations · Cited by this paper
  37. The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease · Ya-Shuo Feng · 2020 · 191 citations · Cited by this paper
  38. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis · SuHyeon Oh · 2023 · 180 citations · Cited by this paper
  39. The Pathogenesis of Mucosal Inflammation in Murine Models of Inflammatory Bowel Disease and Crohn Disease · Warren Strober · 1998 · 163 citations · Cited by this paper

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