Research map: Evaluation of transplacental clearance prediction methods in maternal-fetal PBPK modeling: Implications for predicting fetal drug exposure

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  1. Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008 · Allen A. Mitchell · 2011 · 835 citations · Cited by this paper
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  15. The Human Placental Perfusion Model: A Systematic Review and Development of a Model to Predict In Vivo Transfer of Therapeutic Drugs · Janine R. Hutson · 2011 · 197 citations · Cited by this paper
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  17. Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo · David J. Greenblatt · 1989 · 170 citations · Cited by this paper
  18. A natural deep eutectic system modulates the inflammatory microenvironment and restores pro-regenerative cell functions in in vitro models of chronic wounds · 2026 · Related
  19. Bioavailability of cimetidine in man · Sidney S. Walkenstein · 1978 · 166 citations · Cited by this paper
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  21. Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-( R )-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults · Steven G. Deeks · 1998 · 158 citations · Cited by this paper
  22. Placental transfer of diazepam and its disposition in the newborn · Marinella Mandelli · 1975 · 124 citations · Cited by this paper
  23. Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses · Zufei Zhang · 2017 · 103 citations · Cited by this paper
  24. Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model II: Verification of the Model for Passive Placental Permeability Drugs · Zufei Zhang · 2017 · 94 citations · Cited by this paper
  25. Carbamazepine: Placental Transport, Tissue Concentrations in Foetus and Newborn, and Level in Milk · Seppo Pynnönen · 1977 · 93 citations · Cited by this paper
  26. Bioavailability and pharmacokinetics of cimetidine · A. Grahnén · 1979 · 90 citations · Cited by this paper
  27. Prediction of human fetal pharmacokinetics using ex vivo human placenta perfusion studies and physiologically based models · Maïlys De Sousa Mendes · 2015 · 84 citations · Cited by this paper
  28. A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways · André Dallmann · 2017 · 84 citations · Cited by this paper
  29. Population Pharmacokinetics of Tenofovir in HIV-1-Infected Pregnant Women and Their Neonates (ANRS 12109) · Déborah Hirt · 2008 · 80 citations · Cited by this paper
  30. The pharmacokinetics, safety and efficacy of tenofovir and emtricitabine in HIV-1-infected pregnant women · Angela P. H. Colbers · 2012 · 78 citations · Cited by this paper
  31. Physiologically‐based pharmacokinetic modeling of renally excreted antiretroviral drugs in pregnant women · Maïlys De Sousa Mendes · 2015 · 67 citations · Cited by this paper
  32. Pharmacokinetics and Safety of Tenofovir in HIV-Infected Women During Labor and Their Infants During the First Week of Life · Mark Mirochnick · 2013 · 66 citations · Cited by this paper
  33. Effects of oral contraceptive steroids on acetaminophen metabolism and elimination · Mack C. Mitchell · 1983 · 64 citations · Cited by this paper
  34. Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses · A. Gérardin · 1976 · 63 citations · Cited by this paper
  35. Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N-Acetyl-p-Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women · Paola Mian · 2019 · 63 citations · Cited by this paper
  36. Pharmacokinetics of paracetamol and its metabolites in women at delivery and post‐partum · Aida Kulo · 2012 · 62 citations · Cited by this paper
  37. A Physiologically-Based Pharmacokinetic Model to Predict Human Fetal Exposure for a Drug Metabolized by Several CYP450 Pathways · Maïlys De Sousa Mendes · 2016 · 61 citations · Cited by this paper
  38. Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus · Paola Mian · 2020 · 59 citations · Cited by this paper
  39. Pharmacokinetics and Safety of Single-Dose Tenofovir Disoproxil Fumarate and Emtricitabine in HIV-1-Infected Pregnant Women and Their Infants · Patricia Michele Flynn · 2011 · 57 citations · Cited by this paper

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