Research map: Pharmacological prevention of second primary cancers: From chemoprevention to precision cancer interception

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  1. Oncology Meets Immunology: The Cancer-Immunity Cycle · Daniel S. Chen · 2013 · 7139 citations · Cited by this paper
  2. Targeting key epigenetic regulators in solid tumors: focus on EZH2, PRMT5, and BET inhibitors · 2026 · Related
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  13. Metformin and reduced risk of cancer in diabetic patients · Josie M. M. Evans · 2005 · 2407 citations · Cited by this paper
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  15. Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials · † · 2015 · 1554 citations · Cited by this paper
  16. KRAS G12C-mutant non-small cell lung cancer: A practical guide for clinicians · 2026 · Related
  17. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials · Peter Malcolm Rothwell · 2010 · 1362 citations · Cited by this paper
  18. Targeting HER2 in urothelial carcinoma: from pathway inhibition to antibody–drug conjugates · 2026 · Related
  19. Fusobacterium nucleatum — symbiont, opportunist and oncobacterium · Caitlin A. Brennan · 2018 · 1260 citations · Cited by this paper
  20. Screening and prevention of second primary cancers by hospital-based oncology professionals · 2026 · Related
  21. Randomized Trial of Letrozole Following Tamoxifen as Extended Adjuvant Therapy in Receptor-Positive Breast Cancer: Updated Findings from NCIC CTG MA.17 · Paul Edward Goss · 2005 · 1125 citations · Cited by this paper
  22. Statin Use and Reduced Cancer-Related Mortality · Sune F. Nielsen · 2012 · 1029 citations · Cited by this paper
  23. Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis · Andrea DeCensi · 2010 · 925 citations · Cited by this paper
  24. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial · Norman R. Williams · 2008 · 921 citations · Cited by this paper
  25. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials · Jane Armitage · 2019 · 808 citations · Cited by this paper
  26. The effects of the national HPV vaccination programme in England, UK, on cervical cancer and grade 3 cervical intraepithelial neoplasia incidence: a register-based observational study · Milena Falcaro · 2021 · 792 citations · Cited by this paper
  27. Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2 · Andrew Tan Chan · 2007 · 778 citations · Cited by this paper
  28. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention · Andrew C. Chen · 2015 · 646 citations · Cited by this paper
  29. Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries · Amy Berrington de González · 2011 · 487 citations · Cited by this paper
  30. The microbiome and gynaecological cancer development, prevention and therapy · Paweł Łaniewski · 2020 · 484 citations · Cited by this paper
  31. Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer · Charles E. Geyer · 2022 · 477 citations · Cited by this paper
  32. Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders · Sara Gandini · 2014 · 469 citations · Cited by this paper
  33. Personalized early detection and prevention of breast cancer: ENVISION consensus statement · Nora Pashayan · 2020 · 464 citations · Cited by this paper
  34. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial · John Burn · 2020 · 433 citations · Cited by this paper
  35. Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer · Ravindra Uppaluri · 2025 · 389 citations · Cited by this paper
  36. Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial · I. Ray-Coquard · 2023 · 368 citations · Cited by this paper
  37. Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008 · Nicholas M. Donin · 2016 · 356 citations · Cited by this paper
  38. Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial · Takuma Higurashi · 2016 · 347 citations · Cited by this paper
  39. Structured Exercise after Adjuvant Chemotherapy for Colon Cancer · Kerry S. Courneya · 2025 · 344 citations · Cited by this paper

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