Research map: Emerging Insights and Advances in L-asparaginase: Structural Diversity, Mechanistic Understanding, and Therapeutic Innovations

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Papers in this map

  1. Homogeneous, heterogeneous and enzymatic catalysis for transesterification of high free fatty acid oil (waste cooking oil) to biodiesel: A review · Man Kee Lam · 2010 · 1342 citations · Cited by this paper
  2. Lactobacillus spp. from the Human Gut Microbiota as a Therapeutic Tool in Controlling MRSA-Induced Sepsis · 2025 · Related
  3. Use of ?-asparaginase in childhood ALL · H.-J. Müller · 1998 · 457 citations · Cited by this paper
  4. Antioxidative Defence Mechanisms in Tomato Plants Induced by Biopriming with Trichoderma virens and Jasmonic Acid Against Fusarium Wilt and Damping-Off · 2026 · Related
  5. L-asparaginase in the treatment of patients with acute lymphoblastic leukemia · Rachel A. Egler · 2016 · 339 citations · Cited by this paper
  6. Deciphering Complex Carbohydrate Degrading Potential of Local Hot Spring Isolate Brevibacillus agri MX26 from Tuwa, Gujarat: Purification, Characterization and Genome Annotation · 2025 · Related
  7. Solid state fermentation for production of microbial cellulases: Recent advances and improvement strategies · Sudhanshu S. Behera · 2015 · 273 citations · Cited by this paper
  8. Toward Actionable and Equitable AMR Forecasting: A Standards-First Blueprint Linking Clinical and Environmental Resistomes · 2026 · Related
  9. Dissecting enzyme function with microfluidic-based deep mutational scanning · Philip A. Romero · 2015 · 255 citations · Cited by this paper
  10. Selective Synergy Between Phages and Antibiotics Improves Treatment Outcomes in Staphylococci Infections · 2026 · Related
  11. Current applications and different approaches for microbial l-asparaginase production · Jorge Javier Muso Cachumba · 2016 · 218 citations · Cited by this paper
  12. A Comparative Study on the Efficiency Process of Cellulosic Wastewater Fermentation by Oleaginous Yeasts · 2025 · Related
  13. Structural Basis for the Activity and Substrate Specificity of Erwinia chrysanthemi l -Asparaginase, · Khosrow Aghaiypour · 2001 · 188 citations · Cited by this paper
  14. Sustainable Pigment Synthesis Using Kaas Plateau Bacteria: A Green Approach for Biomedical Applications · 2026 · Related
  15. T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies · Valentina Cordo’ · 2020 · 150 citations · Cited by this paper
  16. Unravelling Cholera’s Footprints in India: A Data-Driven Investigation of its Burden, Risk, and Strain Variability · 2026 · Related
  17. A Novel l -Asparaginase with low l -Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo · Hien Anh Thi Nguyen · 2018 · 130 citations · Cited by this paper
  18. Multiplex Real Time PCR Assay Targeting the eqbE for Rapid Detection and Differentiation of Streptococcus equi from Other Streptococcus Species in Indian Equines · 2026 · Related
  19. Structural and biochemical properties of L‐asparaginase · Jacek T. Lubkowski · 2021 · 110 citations · Cited by this paper
  20. Microbial Electrosynthesis as a Sustainable Platform for Green Chemicals Using CO2 for Circular Bioeconomy · 2026 · Related
  21. Endophytic l-asparaginase-producing fungi from plants associated with anticancer properties · Yiing Yng Chow · 2014 · 102 citations · Cited by this paper
  22. Immobilization of carbonic anhydrase by embedding and covalent coupling into nanocomposite hydrogel containing hydrotalcite · Yatao Zhang · 2009 · 92 citations · Cited by this paper
  23. An insight into plant lipase research – challenges encountered · Sonali Seth · 2013 · 90 citations · Cited by this paper
  24. Isoaspartyl dipeptidase activity of plant-type asparaginases · Mahdi Hejazi · 2002 · 88 citations · Cited by this paper
  25. Crystal Structure of Plant Asparaginase · K. Michalska · 2006 · 87 citations · Cited by this paper
  26. Recent Strategies and Applications for l-Asparaginase Confinement · João C. F. Nunes · 2020 · 86 citations · Cited by this paper
  27. Marine metagenomics as a source for bioprospecting · Rimantas Kodzius · 2015 · 76 citations · Cited by this paper
  28. Biological characterization of L -asparaginase liposomal formulations · Maria Manuela Gaspar · 1996 · 76 citations · Cited by this paper
  29. Purification, characterization and antiproliferative activity of l-asparaginase from Aspergillus oryzae CCT 3940 with no glutaminase activity · Fernanda Furlan Gonçalves Dias · 2016 · 73 citations · Cited by this paper
  30. Synthesis of silk sericin peptides– L ‐asparaginase bioconjugates and their characterization · Yu‐Qing Zhang · 2005 · 69 citations · Cited by this paper
  31. Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions · M. V. Pokrovskaya · 2022 · 61 citations · Cited by this paper
  32. The Mechanism of Autocatalytic Activation of Plant-type L-Asparaginases · K. Michalska · 2008 · 58 citations · Cited by this paper
  33. Structural and biophysical aspects of L -asparaginases: a growing family with amazing diversity · Joanna I. Loch · 2021 · 57 citations · Cited by this paper
  34. Analysis of ethanol–glucose mixtures by two microbial sensors: application of chemometrics and artificial neural networks for data processing · Alexei Lobanov · 2001 · 56 citations · Cited by this paper
  35. L-ASPARAGINASE-AN ANTI TUMOR AGENT PRODUCTION BY FUSARIUM EQUISETI USING SOLID STATE FERMENTATION · Kaliwal Bb · 2011 · 51 citations · Cited by this paper
  36. Structural comparison ofEscherichia coli L -asparaginase in two monoclinic space groups · Mário Sanches · 2003 · 47 citations · Cited by this paper
  37. Liposomal l-asparaginase: in vitro evaluation · M.E.M. Cruz · 1993 · 45 citations · Cited by this paper
  38. Amino acid residues adjacent to the catalytic cavity of tetramer l-asparaginase II contribute significantly to its catalytic efficiency and thermostability · Long Shuiqing · 2015 · 45 citations · Cited by this paper
  39. Plant asparaginase-based asparagine biosensor for leukemia · Kuldeep Kumar · 2012 · 42 citations · Cited by this paper

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