Research map: Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming Innovations

Back to the article

Papers in this map

  1. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis · Sha Mi · 2000 · 1688 citations · Cited by this paper
  2. Lipoprotein(a) as a Cardiovascular Risk Factor: Clinical Significance and Therapeutic Perspectives · 2026 · Related
  3. Promotion of Trophoblast Stem Cell Proliferation by FGF4 · Satoshi Tanaka · 1998 · 1399 citations · Cited by this paper
  4. The Role of Endothelial–Mesenchymal Transition (EndMT) in Aneurysm Formation · 2026 · Related
  5. L1 drives IFN in senescent cells and promotes age-associated inflammation · Marco De Cecco · 2019 · 1317 citations · Cited by this paper
  6. Ectoine Inhibits IL-1β-Induced Inflammation by Suppressing the NF-κB Pathway in Chondrocytes and Alleviates Osteoarthritis in a Rat Model · 2026 · Related
  7. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence · Selene Glück · 2017 · 1214 citations · Cited by this paper
  8. Differential Protective Actions of Dulaglutide and Dexamethasone in Methotrexate Induced Pulmonary Fibrosis: Relationship with AMPK and Beclin-1 Levels · 2026 · Related
  9. BMP4 initiates human embryonic stem cell differentiation to trophoblast · Ren‐He Xu · 2002 · 1157 citations · Cited by this paper
  10. Evolving Landscape of Systemic Therapy for Hepatocellular Carcinoma: From Targeted Therapy and Combination Strategies to Emerging Therapies · 2026 · Related
  11. Tissue-specific mutation accumulation in human adult stem cells during life · Francis Blokzijl · 2016 · 1011 citations · Cited by this paper
  12. Evaluation of Early and Delayed Meloxicam Treatment Against Regulated Cell Death Pathways and ERK1/2 Phosphorylation in a Rat Model of Renal Ischemia–Reperfusion Injury · 2026 · Related
  13. Derivation of Human Trophoblast Stem Cells · Hiroaki Okae · 2017 · 949 citations · Cited by this paper
  14. Overcoming mTOR Inhibitor Resistance: From Biological Basis to Therapeutic Strategies · 2026 · Related
  15. Human placenta and trophoblast development: key molecular mechanisms and model systems · Martin Knöfler · 2019 · 800 citations · Cited by this paper
  16. Region-Specific Proteomic Profiles of Extracellular Vesicles (EVs) Derived from Human Macular and Peripheral RPE-Choroid Explants · 2026 · Related
  17. Trophoblast organoids as a model for maternal–fetal interactions during human placentation · Margherita Y. Turco · 2018 · 722 citations · Cited by this paper
  18. Bioactive Metabolites of Solanum tuberosum L. in Inflammation Modulation and Tissue Regeneration: A Scoping Review of Wound Healing Mechanisms · 2026 · Related
  19. Molecular Criteria for Defining the Naive Human Pluripotent State · Thorold W. Theunissen · 2016 · 538 citations · Cited by this paper
  20. Vardenafil Alleviates Doxorubicin-Induced Cardiotoxicity Associated with Restoration of the AMPK/SIRT1 Signaling Pathway · 2026 · Related
  21. Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta · Sandra Haider · 2018 · 444 citations · Cited by this paper
  22. Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging · Maria M. Mihaylova · 2018 · 438 citations · Cited by this paper
  23. Human naive epiblast cells possess unrestricted lineage potential · Ge Guo · 2021 · 357 citations · Cited by this paper
  24. Derivation of trophoblast stem cells from naïve human pluripotent stem cells · Chen Dong · 2020 · 326 citations · Cited by this paper
  25. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells · Tapash Jay Sarkar · 2020 · 323 citations · Cited by this paper
  26. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast · Cheryl Q. E. Lee · 2016 · 312 citations · Cited by this paper
  27. Spatial multiomics map of trophoblast development in early pregnancy · Anna Arutyunyan · 2023 · 312 citations · Cited by this paper
  28. Capturing human trophoblast development with naive pluripotent stem cells in vitro · Shingo Io · 2021 · 289 citations · Cited by this paper
  29. Organ‐on‐chip models: Implications in drug discovery and clinical applications · Rahul Mittal · 2018 · 235 citations · Cited by this paper
  30. Reprogramming roadmap reveals route to human induced trophoblast stem cells · Xiaodong Liu · 2020 · 215 citations · Cited by this paper
  31. Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome · Jessica K. Cinkornpumin · 2020 · 201 citations · Cited by this paper
  32. Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta · Megan A. Sheridan · 2020 · 195 citations · Cited by this paper
  33. GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency · Christian Krendl · 2017 · 181 citations · Cited by this paper
  34. Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens · Rowan M. Karvas · 2022 · 163 citations · Cited by this paper
  35. Human organoids-on-chips for biomedical research and applications · Hui Wang · 2024 · 133 citations · Cited by this paper
  36. Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta · Sandra Haider · 2022 · 132 citations · Cited by this paper
  37. Trophoblast Cell Subtypes and Dysfunction in the Placenta of Individuals with Preeclampsia Revealed by Single-Cell RNA Sequencing · Wenbo Zhou · 2022 · 128 citations · Cited by this paper
  38. Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy · Qian Li · 2024 · 112 citations · Cited by this paper
  39. Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells · Yanxing Wei · 2021 · 108 citations · Cited by this paper

Source: OpenAlex (CC0)