Research map: Evolution of CRISPR-Cas Detection Systems: From Nucleic Acid Recognition to Omnidirectional Point-of-Care Diagnostic Applications

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Papers in this map

  1. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity · Martin Jínek · 2012 · 17808 citations · Cited by this paper
  2. Programmable nuclease-driven dual/multi-modal biosensors for food safety: CRISPR/Cas and Argonaute systems · Jirong Qin · 2026 · Cites this paper
  3. A Longitudinal EQA-Based Process Sigma Framework for Risk-Oriented Quality Management of Infectious Disease Immunoassays · 2026 · Related
  4. Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase · Craig Tuerk · 1990 · 10507 citations · Cited by this paper
  5. From Rash to Genotype: Rebuilding Measles Outbreak Intelligence in the Post-Elimination Era · 2026 · Related
  6. In vitro selection of RNA molecules that bind specific ligands · Andrew D. Ellington · 1990 · 9888 citations · Cited by this paper
  7. Comparison of genomic and MALDI-TOF MS based proteomic clustering in Enterococcus faecalis · 2026 · Related
  8. CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity · Janice S. Chen · 2018 · 4638 citations · Cited by this paper
  9. High-resolution HAV genotyping using amplicon-based NGS read mapping and quantification · 2026 · Related
  10. Nucleic acid detection with CRISPR-Cas13a/C2c2 · Jonathan S. Gootenberg · 2017 · 4007 citations · Cited by this paper
  11. Dichloran as an antifungal agent in the routine maintenance of leptospiral cultures · 2026 · Related
  12. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector · Omar O. Abudayyeh · 2016 · 2464 citations · Cited by this paper
  13. Rectal carriage with carbapenem-resistant organisms, vancomycin-resistant enterococci, and Clostridioides difficile: insights from a point-prevalence survey in a high-endemic setting · 2026 · Related
  14. CRISPR–Cas9 Structures and Mechanisms · Fuguo Jiang · 2017 · 2126 citations · Cited by this paper
  15. The evolution of tecovirimat resistance in an immunocompromised individual with severe mpox infection · 2026 · Related
  16. SHERLOCK: nucleic acid detection with CRISPR nucleases · Max J. Kellner · 2019 · 1707 citations · Cited by this paper
  17. Diagnostic utility of conventional culture and nucleic acid amplification tests to detect Staphylococcus aureus and Streptococcus pyogenes for the inclusion or exclusion of infection in skin ulcers: An etiologic predictive value analysis · 2026 · Related
  18. Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis · Yuk Ming Dennis Lo · 1998 · 1667 citations · Cited by this paper
  19. Research Progress on Signal Conversion Based on Aptamer Combined CRISPR/Cas System in Biosensors · 2025 · Related
  20. Field-deployable viral diagnostics using CRISPR-Cas13 · Cameron Myhrvold · 2018 · 1521 citations · Cited by this paper
  21. Precise pathogen quantification by CRISPR-Cas: a sweet but tough nut to crack · 2024 · Related
  22. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes · Lucas B. Harrington · 2018 · 1296 citations · Cited by this paper
  23. HOLMESv2: A CRISPR-Cas12b-Assisted Platform for Nucleic Acid Detection and DNA Methylation Quantitation · Linxian X. Li · 2019 · 804 citations · Cited by this paper
  24. Exploring the Trans‐Cleavage Activity of CRISPR‐Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor · Yifan Dai · 2019 · 672 citations · Cited by this paper
  25. DeepCRISPR: optimized CRISPR guide RNA design by deep learning · Guohui Chuai · 2018 · 670 citations · Cited by this paper
  26. Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a · Daan C. Swarts · 2019 · 619 citations · Cited by this paper
  27. The evolutionary journey of Argonaute proteins · Daan C. Swarts · 2014 · 587 citations · Cited by this paper
  28. Size Distributions of Maternal and Fetal DNA in Maternal Plasma · K.C. Allen Chan · 2004 · 581 citations · Cited by this paper
  29. Molecular Mechanisms of RNA Targeting by Cas13-containing Type VI CRISPR–Cas Systems · Mitchell R. O’Connell · 2018 · 363 citations · Cited by this paper
  30. FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences · Jenai Quan · 2019 · 275 citations · Cited by this paper
  31. Droplet Cas12a Assay Enables DNA Quantification from Unamplified Samples at the Single-Molecule Level · Huahua Yue · 2021 · 212 citations · Cited by this paper
  32. Prenatal diagnosis: progress through plasma nucleic acids · Yuk Ming Dennis Lo · 2006 · 199 citations · Cited by this paper
  33. A one-pot CRISPR/Cas13a-based contamination-free biosensor for low-cost and rapid nucleic acid diagnostics · Fei Hu · 2022 · 199 citations · Cited by this paper
  34. Exploiting the orthogonal CRISPR-Cas12a/Cas13a trans-cleavage for dual-gene virus detection using a handheld device · Tian Tian · 2021 · 182 citations · Cited by this paper
  35. Nucleic acid amplification free biosensors for pathogen detection · Yanju Chen · 2020 · 163 citations · Cited by this paper
  36. CRISPR-Based Diagnostics: Challenges and Potential Solutions toward Point-of-Care Applications · Ahmed Ghouneimy · 2022 · 158 citations · Cited by this paper
  37. Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics · Jinzhao Song · 2019 · 156 citations · Cited by this paper
  38. Argonaute proteins: Structural features, functions and emerging roles · Jin’en Wu · 2020 · 135 citations · Cited by this paper
  39. Aptamer assisted CRISPR-Cas12a strategy for small molecule diagnostics · Chenqi Niu · 2021 · 125 citations · Cited by this paper

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