Research map: Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

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Papers in this map

  1. Pathophysiology of Type 2 Diabetes Mellitus · Unai Galicia-García · 2020 · 3336 citations · Cited by this paper
  2. A mouse model of mechanical stress injury to the basal ganglia using thermosensitive PNIPAM hydrogel for intracerebral hemorrhage research · 2026 · Related
  3. Genomic responses in mouse models poorly mimic human inflammatory diseases · Junhee Seok · 2013 · 3064 citations · Cited by this paper
  4. Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics · 2026 · Related
  5. Type 1 diabetes · Mark A. Atkinson · 2013 · 2706 citations · Cited by this paper
  6. A novel mouse model of chronic Pseudomonas aeruginosa infection inducing bronchiectasis‐like phenotype · 2026 · Related
  7. The mechanisms of alloxan- and streptozotocin-induced diabetes · Sigurd Lenzen · 2007 · 2306 citations · Cited by this paper
  8. ApoE ‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration · 2026 · Related
  9. The role of inflammation in insulitis and β-cell loss in type 1 diabetes · Decio Laks Eizirik · 2009 · 1026 citations · Cited by this paper
  10. Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection · 2026 · Related
  11. Streptozotocin‐Induced Diabetic Models in Mice and Rats · Brian L. Furman · 2021 · 888 citations · Cited by this paper
  12. Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats · 2026 · Related
  13. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients · Ken T. Coppieters · 2012 · 680 citations · Cited by this paper
  14. Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts · 2026 · Related
  15. Mouse Models of Human Disease: An Evolutionary Perspective · Robert L. Perlman · 2016 · 665 citations · Cited by this paper
  16. Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter · 2026 · Related
  17. Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs · Jicheng Yu · 2020 · 604 citations · Cited by this paper
  18. USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐ mRNA splicing · 2026 · Related
  19. Modeling type 2 diabetes in rats using high fat diet and streptozotocin · Søs Skovsø · 2014 · 597 citations · Cited by this paper
  20. Time‐course characterization of intraocular pressure in murine steroid‐induced ocular hypertension: Effects of route, schedule, and concentration · 2026 · Related
  21. Role of animal models in biomedical research: a review · Prasenjit Mukherjee · 2022 · 512 citations · Cited by this paper
  22. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. · Susan Bonner‐Weir · 1983 · 470 citations · Cited by this paper
  23. Novel insights into glucocorticoid‐mediated diabetogenic effects: towards expansion of therapeutic options? · Daniël H. van Raalte · 2009 · 439 citations · Cited by this paper
  24. Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice · Élodie Riant · 2009 · 426 citations · Cited by this paper
  25. Regulation of Pancreatic Beta-Cell Mass · Luc Bouwens · 2005 · 413 citations · Cited by this paper
  26. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies · Osasenaga Macdonald. Ighodaro · 2017 · 387 citations · Cited by this paper
  27. Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes · Martha Campbell‐Thompson · 2015 · 367 citations · Cited by this paper
  28. Experimental Diabetes Mellitus in Different Animal Models · Amin Al-Awar · 2016 · 306 citations · Cited by this paper
  29. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes · James Alexander Pearson · 2015 · 305 citations · Cited by this paper
  30. Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance · Carine Beaupère · 2021 · 280 citations · Cited by this paper
  31. Role of glycemic index and glycemic load in the healthy state, in prediabetes, and in diabetes · Gabriele Riccardi · 2008 · 270 citations · Cited by this paper
  32. Spontaneous Diabetes Produced by Selective Breeding of Normal Wistar Rats · Yoshio Gotō · 1975 · 269 citations · Cited by this paper
  33. Use of high-fat diets to study rodent obesity as a model of human obesity · John Roger Speakman · 2019 · 268 citations · Cited by this paper
  34. Experimental animal models for diabetes and its related complications—a review · Chidhambara Priya Dharshini Kottaisamy · 2021 · 267 citations · Cited by this paper
  35. Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin · Francesco Suriano · 2021 · 264 citations · Cited by this paper
  36. Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review · Jibran A. Wali · 2020 · 236 citations · Cited by this paper
  37. Viral infections as potential triggers of type 1 diabetes · Nienke van der Werf · 2006 · 232 citations · Cited by this paper
  38. Blood Sugar Measurement in Zebrafish Reveals Dynamics of Glucose Homeostasis · Stefani C. Eames · 2010 · 220 citations · Cited by this paper
  39. Streptozotocin as a tool for induction of rat models of diabetes: a practical guide · Asghar Ghasemi · 2022 · 210 citations · Cited by this paper

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