Research map: Formulation development and evaluation of nasal in situ gel of promethazine hydrochloride- part II: Pharmacokinetic evaluation and bioavailability studies

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Papers in this map

  1. Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties · Noha M. Zaki · 2007 · 217 citations · Cited by this paper
  2. From particle to performance: Linking size-dependent swelling to disintegration mechanisms in natural plant product tablets · 2026 · Related
  3. Development ofin situgel for nasal delivery: design, optimization,in vitroandin vivoevaluation · Upendra Chandrakant Galgatte · 2013 · 175 citations · Cited by this paper
  4. Perfluorocarbon–liquid interface culture method enhances mucus production and allows evaluation of drug permeability through the mucus layer · 2026 · Related
  5. Resveratrol anchored nanostructured lipid carrier loaded in situ gel via nasal route: Formulation, optimization and in vivo characterization · Amarjitsing Rajput · 2019 · 113 citations · Cited by this paper
  6. In-die compressibility as a surrogate for lubrication-induced changes in tabletability · 2026 · Related
  7. In situ gels of Metoclopramide Hydrochloride for intranasal delivery: In vitro evaluation and in vivo pharmacokinetic study in rabbits · Hitendra Shaligram Mahajan · 2009 · 79 citations · Cited by this paper
  8. Rational design, expression and refolding of a novel bispecific antibody to simultaneously target VEGF-A and Ang-2 for inhibition of angiogenesis · 2026 · Related
  9. Nose-to-Brain Delivery by Nanosuspensions-Based in situ Gel for Breviscapine · Yingchong Chen · 2020 · 64 citations · Cited by this paper
  10. Efficacy of ultraviolet irradiation of pharmaceutical excipients in mitigating N-nitrosamine generation · 2026 · Related
  11. Thermally reversible xyloglucan gels as vehicles for nasal drug delivery · Hitendra Shaligram Mahajan · 2012 · 60 citations · Cited by this paper
  12. Elucidation of intermolecular interaction patterns in quaternary solid dispersion complexes of enzalutamide · 2026 · Related
  13. Intranasal In Situ Gel of Apixaban-Loaded Nanoethosomes: Preparation, Optimization, and In Vivo Evaluation · Ahmed A. El-Shenawy · 2021 · 55 citations · Cited by this paper
  14. Niclosamide ethanolamine induces malignant phyllodes tumor cell death via mTOR-TFEB axis-mediated lysosomal biogenesis and functional uncoupling · 2026 · Related
  15. Nasal In Situ Gel: Novel Approach for Nasal Drug Delivery · Anjali Sunil Sabale · 2020 · 48 citations · Cited by this paper
  16. Correlation between protein-polydimethylsiloxane visible particle formation and computationally derived antibody surface properties · 2026 · Related
  17. A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study · Yifan Chen · 2019 · 43 citations · Cited by this paper
  18. Identification of a diastereomer of penicilloic acid during acid-mediated degradation of 6-aminopenicillanic acid · 2026 · Related
  19. Ion-Triggered In Situ Gelling Nanoemulgel as a Platform for Nose-to-Brain Delivery of Small Lipophilic Molecules · Nagaraja Sreeharsha · 2021 · 37 citations · Cited by this paper
  20. Mechanistic advances in nanomedicine, nucleic acid therapies, and AI-driven research on cervical cancer · 2026 · Related
  21. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects · Laura C. Strenkoski‐Nix · 2000 · 36 citations · Cited by this paper
  22. Ondansetron-loaded chitosan microspheres for nasal antiemetic drug delivery: an alternative approach to oral and parenteral routes · Sevgi Güngör · 2010 · 36 citations · Cited by this paper
  23. Buspirone Hydrochloride Loaded In Situ Nanovesicular Gel as an Anxiolytic Nasal Drug Delivery System: In Vitro and Animal Studies · Dina M. Abdelnabi · 2019 · 35 citations · Cited by this paper
  24. Piribedil loaded thermo-responsive nasal in situ gelling system for enhanced delivery to the brain: formulation optimization, physical characterization, and in vitro and in vivo evaluation · Chandra Teja Uppuluri · 2020 · 32 citations · Cited by this paper
  25. Thermosensitive nasal in situ gelling systems of rufinamide formulated using modified tamarind seed xyloglucan for direct nose-to-brain delivery: design, physical characterization, and in vivo evaluation · Avantika V. Dalvi · 2021 · 28 citations · Cited by this paper
  26. Development and In Vitro Characterization of Chitosan-based Microspheres for Nasal Delivery of Promethazine · Anita Hafner · 2007 · 24 citations · Cited by this paper
  27. Absorption rate and bioavailability of promethazine from rectal and oral dosage forms · Frits Moolenaar · 1981 · 23 citations · Cited by this paper
  28. Formulation development and evaluation of nasal in situ gel of promethazine hydrochloride · Surabhi V. Boraste · 2023 · 21 citations · Cited by this paper
  29. BIOAVAILABILITY OF INTRANASAL PROMETHAZINE DOSAGE FORMS IN DOGS · Raghupathy Ramanathan · 1998 · 18 citations · Cited by this paper
  30. Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation · Md Ali Mujtaba · 2025 · 15 citations · Cited by this paper
  31. Development of in vitro and in vivo evaluation of mucoadhesive in-situ gel for intranasal delivery of vinpocetine · Sumaia Abdulbari Ahmed Ali Hard · 2024 · 14 citations · Cited by this paper
  32. Determination of Promethazine in Biological Fluids · Glyn Taylor · 1979 · 13 citations · Cited by this paper
  33. Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: A motion sickness medication · Joe A. McDonough · 2007 · 12 citations · Cited by this paper
  34. Determinants of systemic availability of promethazine in rabbits · Glyn Taylor · 1983 · 12 citations · Cited by this paper
  35. Nasal Administration of Dolutegravir Loaded Nanoparticles Based Mucoadhesive in situ Gel: Design and in vivo Assessment · Nagaraja Sreeharsha · 2024 · 8 citations · Cited by this paper
  36. Pharmacokinetic Study of Mucoadhesive Itopride Hydrochloride In Situ Nasal Gel Formulations in a Comparative In Vivo Study and Histopathological Safety Evaluation · Maha A. Marzouk · 2022 · 7 citations · Cited by this paper

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