Research map: Glioblastoma and resistance to radiotherapy: role of cancer stem cells subpopulations, hypoxia and therapeutic strategies

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  1. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 · Roel G.W. Verhaak · 2010 · 7881 citations · Cited by this paper
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  3. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial · Roger Stupp · 2009 · 7879 citations · Cited by this paper
  4. Pharmacological prevention of second primary cancers: From chemoprevention to precision cancer interception · 2026 · Related
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  9. A restricted cell population propagates glioblastoma growth after chemotherapy · Jian Chen · 2012 · 2367 citations · Cited by this paper
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  11. Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells · Zhizhong Li · 2009 · 1354 citations · Cited by this paper
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  13. Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma · Krishna Bhat · 2013 · 1165 citations · Cited by this paper
  14. Is Cytoreductive surgery for unresectable colorectal liver metastases able to improve patient outcome? Results of a pilot prospective study · 2026 · Related
  15. Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion · Humsa S. Venkatesh · 2015 · 1005 citations · Cited by this paper
  16. KRAS G12C-mutant non-small cell lung cancer: A practical guide for clinicians · 2026 · Related
  17. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia · Robert D. Guzy · 2006 · 888 citations · Cited by this paper
  18. Targeting HER2 in urothelial carcinoma: from pathway inhibition to antibody–drug conjugates · 2026 · Related
  19. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype · John M. Heddleston · 2009 · 810 citations · Cited by this paper
  20. Biomarker-guided immunotherapy in gastric cancer: current insights and future perspectives · 2026 · Related
  21. Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3 · Ping Mao · 2013 · 655 citations · Cited by this paper
  22. Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy · Brenda Auffinger · 2014 · 359 citations · Cited by this paper
  23. Control of mitochondrial superoxide production by reverse electron transport at complex I · Ellen L. Robb · 2018 · 335 citations · Cited by this paper
  24. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages · Teresa E. Peterson · 2016 · 322 citations · Cited by this paper
  25. Epithelial-mesenchymal transition in glioblastoma progression · Yasuo Iwadate · 2016 · 295 citations · Cited by this paper
  26. VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2 · Dekuang Zhao · 2014 · 269 citations · Cited by this paper
  27. Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition · Anna Segerman · 2016 · 258 citations · Cited by this paper
  28. Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling · Yueh‐Te Lin · 2020 · 250 citations · Cited by this paper
  29. Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma · Monica Fedele · 2019 · 244 citations · Cited by this paper
  30. Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation · Mutsuko Minata · 2019 · 225 citations · Cited by this paper
  31. Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma · Lan Hoang-Minh · 2018 · 196 citations · Cited by this paper
  32. Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance · Perrine Dahan · 2014 · 192 citations · Cited by this paper
  33. Cancer stem cells: landscape, challenges and emerging therapeutic innovations · Haksoo Lee · 2025 · 181 citations · Cited by this paper
  34. Tumor treating fields: a novel treatment modality and its use in brain tumors · Andreas Felix Hottinger · 2016 · 180 citations · Cited by this paper
  35. Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair · Shujun Fu · 2019 · 175 citations · Cited by this paper
  36. A phase I/II study of sepantronium bromide (YM155, survivin suppressor) with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer · Ronan Joseph Kelly · 2013 · 173 citations · Cited by this paper
  37. Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization · Delphine Garnier · 2017 · 152 citations · Cited by this paper
  38. When dormancy fuels tumour relapse · Karla Santos-de-Frutos · 2021 · 145 citations · Cited by this paper
  39. ERK/GSK3β/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition · Devipriya Nagarajan · 2011 · 141 citations · Cited by this paper

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