Research map: Characteristics Three waves of pyripyropene fungal alkaloids and synthetic derivatives targeting ACAT2 as insecticides, anti-atherosclerosis and anticancer agents.

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Papers in this map

  1. Fungal secondary metabolism: regulation, function and drug discovery · Nancy P. Keller · 2018 · 1459 citations · Cited by this paper
  2. Low-molecular-weight fucoidan inhibits HMGB1-induced thromboinflammation by modulating HMGB1-TLR4 axis · 2026 · Related
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  4. Poly(I:C) and QS-21 combination suppresses breast tumor growth and metastasis by repolarizing tumor associated macrophages to anti-tumor macrophages · 2026 · Related
  5. Biosynthesis of fungal meroterpenoids · Yudai Matsuda · 2015 · 437 citations · Cited by this paper
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  7. Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases · Takayuki Itoh · 2010 · 239 citations · Cited by this paper
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  9. ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver · Paolo Parini · 2004 · 222 citations · Cited by this paper
  10. CTSB-Associated Inflammation and Macrophage Interaction in Heart Failure Following Myocardial Infarction and Potential Therapeutic Implications of Quercetin · 2026 · Related
  11. The contribution of fungi to the global economy · Allen Grace T. Niego · 2023 · 185 citations · Cited by this paper
  12. S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis · 2026 · Related
  13. Metabolomics ofAspergillus fumigatus · Jens C. Frisvad · 2008 · 161 citations · Cited by this paper
  14. Induction and Propagation of Ferroptosis Evasion by FTH1P7 Drives Sorafenib Resistance in Hepatocellular Carcinoma · 2026 · Related
  15. A Formal [3 + 3] Cycloaddition Approach to Natural‐Product Synthesis · Richard P. Hsung · 2004 · 158 citations · Cited by this paper
  16. A functional coupling of TRPA1 and TMEM16A channels regulates endothelium-dependent hyperpolarization-mediated vasorelaxation of mesenteric resistance arteries in healthy and septic mice · 2026 · Related
  17. Pyripyropenes, highly potent inhibitiors of ACYL-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. · Satoshi Ōmura · 1993 · 155 citations · Cited by this paper
  18. Role of Abca7-related microglial responses in linking type 2 diabetes mellitus to Alzheimer's disease progression: Evidence from single-cell transcriptomic analysis and experimental validation in animal and cell models · 2026 · Related
  19. Afidopyropen: New and potent modulator of insect transient receptor potential channels · Ramani A. Kandasamy · 2017 · 143 citations · Cited by this paper
  20. Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization · 2025 · Related
  21. Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay · Aaron T. Lada · 2004 · 136 citations · Cited by this paper
  22. Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties. · Hiroshi Tomoda · 1994 · 135 citations · Cited by this paper
  23. The recent insights into the function of ACAT1: A possible anti-cancer therapeutic target · Afsaneh Goudarzi · 2019 · 113 citations · Cited by this paper
  24. Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D. · Young Kook Kim · 1994 · 108 citations · Cited by this paper
  25. New Isocoumarin Derivatives and Meroterpenoids from the Marine Sponge-Associated Fungus Aspergillus similanensis sp. nov. KUFA 0013 · Chadaporn Prompanya · 2014 · 87 citations · Cited by this paper
  26. Pyripyropene A, an Acyl–Coenzyme A:Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia · Taichi Ohshiro · 2011 · 87 citations · Cited by this paper
  27. Selectivity of Microbial Acyl-CoA : cholesterol Acyltransferase Inhibitors toward Isozymes · Taichi Ohshiro · 2007 · 85 citations · Cited by this paper
  28. Relative and Absolute Stereochemistry of Pyripyropene A, A Potent, Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase (ACAT) · Hiroshi Tomoda · 1994 · 84 citations · Cited by this paper
  29. Total Synthesis of (+)-Pyripyropene A, a Potent, Orally Bioavailable Inhibitor of Acyl-CoA:Cholesterol Acyltransferase · Tohru Nagamitsu · 1995 · 80 citations · Cited by this paper
  30. Exploring the Chemodiversity and Biological Activities of the Secondary Metabolites from the Marine Fungus Neosartorya pseudofischeri · Wanling Liang · 2014 · 79 citations · Cited by this paper
  31. Chemistry of fungal meroterpenoid cyclases · Lena Barra · 2020 · 75 citations · Cited by this paper
  32. Histone lactylation-driven feedback loop modulates cholesterol-linked immunosuppression in pancreatic cancer · Jing Yang · 2025 · 75 citations · Cited by this paper
  33. Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites · Toshiaki Sunazuka · 2005 · 74 citations · Cited by this paper
  34. A New Cyclic Hexapeptide and a New Isocoumarin Derivative from the Marine Sponge-Associated Fungus Aspergillus similanensis KUFA 0013 · Chadaporn Prompanya · 2015 · 72 citations · Cited by this paper
  35. An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus · Abigail Lind · 2018 · 72 citations · Cited by this paper
  36. Pyripyropenes, Novel ACAT Inhibitors Produced by Aspergillus fumigatus. III. Structure Elucidation of Pyripyropenes E to L. · Hiroshi Tomoda · 1995 · 69 citations · Cited by this paper
  37. Tomatidine, a Tomato Sapogenol, Ameliorates Hyperlipidemia and Atherosclerosis in ApoE-Deficient Mice by Inhibiting Acyl-CoA:cholesterol Acyl-transferase (ACAT) · Yukio Fujiwara · 2011 · 67 citations · Cited by this paper
  38. Fungal Drug Discovery for Chronic Disease: History, New Discoveries and New Approaches · Thomas A. K. Prescott · 2023 · 67 citations · Cited by this paper
  39. Exploiting PdII and TiIII Chemistry To Obtain γ-Dioxygenated Terpenoids: Synthesis of Rostratone and Novel Approaches to Aphidicolin and Pyripyropene A · José Justicia · 2005 · 58 citations · Cited by this paper

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