Research map: Sex‐Related Differences in Physiologically‐Based Biopharmaceutics Modeling

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Papers in this map

  1. Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions · Trudy Rodgers · 2006 · 957 citations · Cited by this paper
  2. Follow‐Up Bias in Tumor Dynamic Modeling: A Comparison of Classical and Neural‐ODE Approaches · 2026 · Related
  3. Sex differences in pharmacokinetics predict adverse drug reactions in women · Irving Zucker · 2020 · 813 citations · Cited by this paper
  4. Evaluating Preclinical‐to‐Human Bioavailability Classification Using Smooth ROC Curve Estimation · 2026 · Related
  5. Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases · Trudy Rodgers · 2005 · 785 citations · Cited by this paper
  6. Population Pharmacokinetics and Pharmacodynamics of Paracetamol in Malaysian Patients With Plasmodium knowlesi Malaria · 2026 · Related
  7. Characterization of Fluids from the Stomach and Proximal Jejunum in Men and Women · Anders H. Lindahl · 1997 · 412 citations · Cited by this paper
  8. Hybrid Systems Modeling of Donor T‐Cell Responses and Graft‐Versus‐Host‐Disease After Posttransplantation Cyclophosphamide Administration · 2026 · Related
  9. Variability of gastrointestinal transit in healthy women and men. · Lukas P. Degen · 1996 · 346 citations · Cited by this paper
  10. Assessing Covariate Clinical Relevance in High‐Dimensional PK Analysis: A Comparison of SCM +, FFEM , and FREM Approaches · 2026 · Related
  11. Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review · Cordula Stillhart · 2020 · 316 citations · Cited by this paper
  12. Integrative QSP Modeling of Cancer Stem Cells in Triple‐Negative Breast Cancer: Impacts on Tumor Immunity and Response to Immune Checkpoint Inhibitors · 2026 · Related
  13. Influence of gender and menopause on gastric emptying and motility · William R. Hutson · 1989 · 313 citations · Cited by this paper
  14. Physiologically Based Pharmacokinetic Model of Brigatinib in Healthy Volunteers and Patients With Cancer · 2026 · Related
  15. Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery · Ana C. Freire · 2011 · 191 citations · Cited by this paper
  16. Objective First, Method Second: Why the Estimand Definition Comes First in Pharmacometric Covariate Modeling · 2026 · Related
  17. Let’s talk about sex: Differences in drug therapy in males and females · Christine M. Madla · 2021 · 168 citations · Cited by this paper
  18. Butorphanol Pharmacokinetics Across Species: Meta‐Analysis Integrating Allometric Scaling and Minimal Physiologically Based Pharmacokinetic Modeling · 2026 · Related
  19. Influence of age, gender, hormonal status and smoking habits on colonic transit time · Remy F. Meier · 1995 · 149 citations · Cited by this paper
  20. Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature · André Farkouh · 2019 · 136 citations · Cited by this paper
  21. Sex differences in colonic function: a randomised trial. · Johanna W. Lampe · 1993 · 132 citations · Cited by this paper
  22. Comparison of total and compartmental gastric emptying and antral motility between healthy men and women · Roelof J. Bennink · 1998 · 103 citations · Cited by this paper
  23. Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Ketoprofen · Igor E. Shohin · 2012 · 98 citations · Cited by this paper
  24. Fasting gastric pH and its relationship to true hypochlorhydria in humans · Mark L. Feldman · 1991 · 94 citations · Cited by this paper
  25. Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral administration · Takashi Ishizaki · 1980 · 89 citations · Cited by this paper
  26. Use of biorelevant dissolution and PBPK modeling to predict oral drug absorption · Navpreet Kaur · 2018 · 75 citations · Cited by this paper
  27. Physiologically Based Biopharmaceutics Modeling (PBBM): Best Practices for Drug Product Quality, Regulatory and Industry Perspectives: 2023 Workshop Summary Report · Claire E. Mackie · 2024 · 67 citations · Cited by this paper
  28. Applications of PBPK/PBBM modeling in generic product development: An industry perspective · K Yuvaneshwari · 2022 · 59 citations · Cited by this paper
  29. Gastrointestinal Water and Electrolytes. IV. The Equilibration of Deuterium Oxide (D2O) in Gastrointestinal Contents and the Proportion of Total Body Water (T.B.W.) in the Gastrointestinal Tract1 · Frank A. Gotch · 1957 · 58 citations · Cited by this paper
  30. Clinical Pharmacokinetics of Ketoprofen After Single Intravenous Administration as a Bolus or Infusion · Danièle Debruyne · 1987 · 52 citations · Cited by this paper
  31. Bioavailability of a new ketoprofen formulation for once-daily oral administration · Aldo Roda · 2002 · 46 citations · Cited by this paper
  32. Sex Effect on Average Bioequivalence · Manuel Ibarra · 2016 · 41 citations · Cited by this paper
  33. Ketoprofen pharmacokinetics and bioavailability based on an improved sensitive and specific assay · Robert A. Upton · 1981 · 40 citations · Cited by this paper
  34. Physiologically based pharmacokinetic (PBPK) modelling of oral drug absorption in older adults – an AGePOP review · Cleo Demeester · 2023 · 32 citations · Cited by this paper
  35. Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost · Vaishali Sahasrabudhe · 2025 · 32 citations · Cited by this paper
  36. Power of integrating PBPK with PBBM (PBPK-BM): a single model predicting food effect, gender impact, drug-drug interactions and bioequivalence in fasting & fed conditions · Rajkumar Boddu · 2023 · 19 citations · Cited by this paper
  37. Sex and Food Influence on Intestinal Absorption of Ketoprofen Gastroresistant Formulation · Laura Magallanes · 2015 · 16 citations · Cited by this paper
  38. Progressive tools and critical strategies for development of best fit PBPK model aiming better in vitro–in vivo correlation · A.R. Golhar · 2023 · 15 citations · Cited by this paper
  39. Evaluating gender effect in the generic bioequivalence studies by physiologically based pharmacokinetic modeling – A case study of dextromethorphan modified release tablets · Manoj Gundeti · 2024 · 3 citations · Cited by this paper

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