Research map: Peptide Loading Complex in Cancer: From Peptide Translocation, Editing, and Loading into MHC-I to a Potential Therapeutic Target

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  1. The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data · Ethan G Cerami · 2012 · 18797 citations · Cited by this paper
  2. METTL3–m6A–LOXL2 Axis Post-Transcriptionally Fine-Tunes Macrophage Migration and Invasion · 2026 · Related
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  9. Towards a systems understanding of MHC class I and MHC class II antigen presentation · Jacques Neefjes · 2011 · 2075 citations · Cited by this paper
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  11. MicroRNAs in Cancer · Gianpiero Di Leva · 2013 · 1752 citations · Cited by this paper
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  13. Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation · Karthik Dhatchinamoorthy · 2021 · 1107 citations · Cited by this paper
  14. Strategies for Evading Cellular Immunity Against Recombinant AAV Vectors in Gene Therapy · 2026 · Related
  15. MicroRNAs in Development and Disease · Danish H Sayed · 2011 · 1083 citations · Cited by this paper
  16. Advances and Clinical Applications of Thrombopoietic Agents · 2026 · Related
  17. Targeting neoantigens to augment antitumour immunity · Mark M. Yarchoan · 2017 · 1055 citations · Cited by this paper
  18. Bone Morphogenetic Proteins in Obesity Management: Therapeutic Potential and Challenges Beyond the Skeleton · 2026 · Related
  19. Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation · Marek Wieczorek · 2017 · 1052 citations · Cited by this paper
  20. Matrix Competence Failure in Osteoporosis: Mechanosensing, Osteoimmune Crosstalk, and Fragility Beyond Bone Mineral Density · 2026 · Related
  21. Present Yourself! By MHC Class I and MHC Class II Molecules · Kenneth L. Rock · 2016 · 847 citations · Cited by this paper
  22. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells · Luc Van Kaer · 1992 · 731 citations · Cited by this paper
  23. Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi · Amila Suraweera · 2018 · 677 citations · Cited by this paper
  24. Identification of human cancers deficient in antigen processing. · Nicholas P. Restifo · 1993 · 632 citations · Cited by this paper
  25. STAT3 Target Genes Relevant to Human Cancers · Richard L. Carpenter · 2014 · 541 citations · Cited by this paper
  26. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides · Maria L. Wei · 1992 · 502 citations · Cited by this paper
  27. MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy · Annelisa M. Cornel · 2020 · 479 citations · Cited by this paper
  28. Neoantigen landscape dynamics during human melanoma–T cell interactions · Els M.E. Verdegaal · 2016 · 472 citations · Cited by this paper
  29. Antigen-processing machinery breakdown and tumor growth · Barbara Seliger · 2000 · 460 citations · Cited by this paper
  30. Immunoproteasomes · Deborah A. Ferrington · 2012 · 423 citations · Cited by this paper
  31. Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing · Sofia R. Gameiro · 2013 · 415 citations · Cited by this paper
  32. Structure of the human MHC-I peptide-loading complex · Andreas Blees · 2017 · 401 citations · Cited by this paper
  33. Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens · Anne L. Ackerman · 2003 · 382 citations · Cited by this paper
  34. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression · Qingsong Hu · 2019 · 378 citations · Cited by this paper
  35. Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin · Anthony Peter Williams · 2002 · 359 citations · Cited by this paper
  36. Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. · FV Cromme · 1994 · 339 citations · Cited by this paper
  37. Selectivity of MHC-encoded peptide transporters from human, mouse and rat · Frank Momburg · 1994 · 337 citations · Cited by this paper
  38. The nature of the MHC class I peptide loading complex · Peter Cresswell · 1999 · 334 citations · Cited by this paper
  39. NLRC5/MHC class I transactivator is a target for immune evasion in cancer · Sayuri Yoshihama · 2016 · 285 citations · Cited by this paper

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