Research map: Macrophage-driven inflammation in inflammatory bowel disease: mechanisms and therapeutic opportunities

Back to the article

Papers in this map

  1. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease · Luke Jostins · 2012 · 4925 citations · Cited by this paper
  2. Multimodal assessment of liver stiffness and portal hemodynamics in a cirrhotic mouse model · 2026 · Related
  3. Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis · Seth Rakoff-Nahoum · 2004 · 4278 citations · Cited by this paper
  4. Bridging physics and biology in acupuncture: flexible multimodal bioelectronics for decoding the deqi microenvironment · 2026 · Related
  5. Trained immunity: A program of innate immune memory in health and disease · Mihai Gheorghe Netea · 2016 · 2828 citations · Cited by this paper
  6. From coal biodesulfurization to mine-soil remediation: a critical review of microbial sulfur transformation in coal-impacted environments · 2026 · Related
  7. Defining trained immunity and its role in health and disease · Mihai Gheorghe Netea · 2020 · 2715 citations · Cited by this paper
  8. Gait assessment using a 2D video-based pose estimation app in comparison to a markerless motion capture system in subjects with osteoarthritis of the knee – a pilot study · 2026 · Related
  9. mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity · Shih‐Chin Cheng · 2014 · 2272 citations · Cited by this paper
  10. Trunk rotation coordination in front crawl: which segment leads? Three coordination strategies and their dynamic changes across 400-m split progression in elite swimmers · 2026 · Related
  11. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition · Pamela V. Chang · 2014 · 2217 citations · Cited by this paper
  12. Diagnosing soil bioremediation failure: evidence-weighted pathways from mechanism to field closure · 2026 · Related
  13. Gut microbiota-derived metabolites as key actors in inflammatory bowel disease · Aonghus Lavelle · 2020 · 2067 citations · Cited by this paper
  14. Modeling process instability in anaerobic digestion by using a thermodynamically corrected model · 2026 · Related
  15. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity · Sadia Saeed · 2014 · 1805 citations · Cited by this paper
  16. Can cervical disc herniations be provoked in vitro? · 2026 · Related
  17. Trained Immunity: A Memory for Innate Host Defense · Mihai Gheorghe Netea · 2011 · 1712 citations · Cited by this paper
  18. Microbiota-derived metabolites in inflammatory bowel disease · 2025 · Related
  19. Immunopathogenesis of IBD: current state of the art · Heitor Siffert Pereira de Souza · 2015 · 1577 citations · Cited by this paper
  20. Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting · 2026 · Related
  21. Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis · Christopher S. Smillie · 2019 · 1542 citations · Cited by this paper
  22. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome · Laurence Macia · 2015 · 1470 citations · Cited by this paper
  23. Pathophysiology of Inflammatory Bowel Diseases · John T. Chang · 2020 · 1325 citations · Cited by this paper
  24. Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes · Jessica Quintin · 2012 · 1316 citations · Cited by this paper
  25. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice · Calum C. Bain · 2014 · 1203 citations · Cited by this paper
  26. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity · Ioannis Mitroulis · 2018 · 1122 citations · Cited by this paper
  27. Mechanisms of Disease: Inflammatory Bowel Diseases · Guilherme Piovezani Ramos · 2019 · 1041 citations · Cited by this paper
  28. The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis · Hasan Zaki · 2010 · 992 citations · Cited by this paper
  29. Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD · Yi Rang Na · 2019 · 932 citations · Cited by this paper
  30. Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy · J. P. D. Martin · 2019 · 932 citations · Cited by this paper
  31. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome · Christian Alexander Bauer · 2010 · 923 citations · Cited by this paper
  32. Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity · Rob J.W. Arts · 2016 · 911 citations · Cited by this paper
  33. NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion · Marta Wlodarska · 2014 · 718 citations · Cited by this paper
  34. Paracellular permeability and tight junction regulation in gut health and disease · Arie Horowitz · 2023 · 687 citations · Cited by this paper
  35. NLRP3 Inflammasome and Inflammatory Bowel Disease · Zhen Yu · 2019 · 666 citations · Cited by this paper
  36. Pathophysiology of Inflammatory Bowel Disease: Innate Immune System · Ángela Saéz · 2023 · 574 citations · Cited by this paper
  37. Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis · Ehud Zigmond · 2014 · 561 citations · Cited by this paper
  38. GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis · Amanda J. Littlewood-Evans · 2016 · 526 citations · Cited by this paper
  39. Trained immunity — basic concepts and contributions to immunopathology · Jordi Ochando · 2022 · 457 citations · Cited by this paper

Source: OpenAlex (CC0)