Research map: Impaired PD-1 expression in tumor-infiltrating senescent CD8+ T cells is reversed by PD-L1 blockade in a murine squamous cell carcinoma model
Back to the article
Papers in this map
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
· Carol Kilkenny · 2010 · 7468 citations · Cited by this paper
ROS-scavenging and antibacterial properties of polydopamine-coated, drug-loaded bovine serum albumin nanoparticles
· 2026 · Related
Head and neck squamous cell carcinoma
· Daniel E. Johnson · 2020 · 4229 citations · Cited by this paper
The Runx2-SMOC axis in skeletal development: Expanding roles of Smoc1 and Smoc2 in development and disease
· 2026 · Related
Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance
· Sreya Bagchi · 2020 · 2280 citations · Cited by this paper
Oral SARS-CoV-2 inoculation leads to distinct viral distribution compared to nasal inoculation in a Syrian hamster model
· 2026 · Related
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
· Brian C. Miller · 2019 · 2185 citations · Cited by this paper
Elucidating disease pathogenesis using formalin-fixed paraffin-embedded samples: Integrating genomics, spatial transcriptomics, and histology – A focus on vascular anomalies
· 2026 · Related
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
· Laura M. McLane · 2019 · 2088 citations · Cited by this paper
Protein fractions associated with Prevotella intermedia suppress the growth of HSC-3 oral squamous cell carcinoma cells
· 2026 · Related
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
· Imran A. P. Siddiqui · 2019 · 1739 citations · Cited by this paper
LepR+ skeletal stem/progenitor cells in craniofacial tissues
· 2026 · Related
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
· Alena Gros · 2014 · 1139 citations · Cited by this paper
Sublingual glands show the highest frequency of IgA positive cells among murine major salivary glands
· 2026 · Related
TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
· Zeyu Chen · 2019 · 740 citations · Cited by this paper
Orthodontic force induces local bone resorption in mild-type hypophosphatasia mouse model
· 2026 · Related
The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes
· Floris F. Dammeijer · 2020 · 708 citations · Cited by this paper
Mechanisms of metabolic dysfunction-associated steatohepatitis progression induced by periodontitis and therapeutic strategies
· 2026 · Related
Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
· Sema Kurtuluş · 2019 · 679 citations · Cited by this paper
Immunosenescence: a key player in cancer development
· Jingyao Lian · 2020 · 528 citations · Cited by this paper
Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review
· Barbora Peltanová · 2019 · 498 citations · Cited by this paper
Precursor exhausted T cells: key to successful immunotherapy?
· Axel Kallies · 2019 · 491 citations · Cited by this paper
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
· Teh‐Wei Wang · 2022 · 490 citations · Cited by this paper
Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma
· Patcharee Ritprajak · 2014 · 315 citations · Cited by this paper
Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells
· Kylie M. Quinn · 2018 · 274 citations · Cited by this paper
Cellular senescence and SASP in tumor progression and therapeutic opportunities
· Zening Dong · 2024 · 250 citations · Cited by this paper
Virtual memory CD8 T cells display unique functional properties
· June‐Yong Lee · 2013 · 174 citations · Cited by this paper
Cutting Edge: Central Memory CD8 T Cells in Aged Mice Are Virtual Memory Cells
· Bo‐Chin Chiu · 2013 · 144 citations · Cited by this paper
Differential contribution of three immune checkpoint (VISTA, CTLA-4, PD-1) pathways to antitumor responses against squamous cell carcinoma
· Yuta Kondo · 2016 · 142 citations · Cited by this paper
Immunosenescence and inflammaging: Mechanisms and role in diseases
· Amir Ajoolabady · 2024 · 136 citations · Cited by this paper
Predominant expression of B7-H1 and its immunoregulatory roles in oral squamous cell carcinoma
· Fumihiko Tsushima · 2005 · 105 citations · Cited by this paper
The aged tumor microenvironment limits T cell control of cancer
· Chang-Yu Chen · 2024 · 104 citations · Cited by this paper
Aging, cancer, and antitumor immunity
· Hideki Ikeda · 2021 · 70 citations · Cited by this paper
The effects of aging on tumor growth and angiogenesis are tumor‐cell dependent
· May J. Reed · 2006 · 53 citations · Cited by this paper
TCF-1 maintains CD8+ T cell stemness in tumor microenvironment
· Shuqiong Wen · 2021 · 39 citations · Cited by this paper
Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy
· Naoto Nishii · 2018 · 36 citations · Cited by this paper
PD-1 Blockade Unleashes Effector Potential of Both High- and Low-Affinity Tumor-Infiltrating T Cells
· Amaia Martínez-Usatorre · 2018 · 30 citations · Cited by this paper
Immune checkpoint expression and relationships to anti‐PD‐L1 immune checkpoint blockade cancer immunotherapy efficacy in aged versus young mice
· Myrna G Garcia · 2022 · 29 citations · Cited by this paper
Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity
· Peter Georgiev · 2024 · 25 citations · Cited by this paper
Source: OpenAlex (CC0)