Immunotherapy Targeting Tumor-Associated Macrophages

Frontiers in Medicine · Published 2020-11-05 · Journal article · DOI 10.3389/fmed.2020.583708 · Cited by 23 (Crossref)

Authors (2)

Yafei Liu, Rongsi Wang

Abstract

Macrophages are phagocytic cells that play a broad role in maintaining body homeostasis and defense against foreign pathogens; whereas tumor-associated macrophages (TAMs) support tumor growth and metastasis by promoting cancer cell proliferation and invasion, immunosuppression, and angiogenesis, which is closely related to the poor prognosis in almost all solid tumors. Hence, deep-insight knowledge into TAMs can provide an opportunity to discover more effective strategies for cancer therapeutics. So far, a large number of therapeutic agents targeting TAMs are in clinical trials. In this review, we introduce an extensive overview about macrophages and macrophage-targeting agents.

Abstract from DOAJ. Public domain (CC0 1.0).

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Publication details

Volume

7

Year

2020

Citation

Liu, Y., Wang, R. (2020). Immunotherapy Targeting Tumor-Associated Macrophages. Frontiers in Medicine. https://doi.org/10.3389/fmed.2020.583708

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Citations (Crossref)

23