Transplantation Reports · Published 2026-06-24 · DOI 10.1016/j.tpr.2026.100208
Caiwei Li, Xianliang Jiang, Ifeanyi Christian Onyebuchi, Lan Cheng, Chuankai Zhang, Li Ke, Jian Huang
Lung transplantation remains a critical therapeutic option for patients with end-stage pulmonary diseases, yet postoperative management continues to face significant challenges including immune rejection, infections, and graft dysfunction. Traditional immunosuppressive regimens, while effective, are often associated with adverse effects and complications, prompting the search for adjunctive therapies with improved safety profiles. In recent years, natural compounds have gained increasing attention due to their multi-target regulatory properties and relatively low toxicity, positioning them as promising candidates for post-lung transplantation adjuvant treatment. This review comprehensively summarizes the latest research progress on the application of natural compounds in modulating immune responses, reducing inflammation, and preventing fibrosis after lung transplantation. We explore the underlying molecular mechanisms through which these compounds exert their effects, such as modulation of immune cell activity, cytokine regulation, and inhibition of fibrotic pathways. Additionally, the review discusses the current challenges and future clinical prospects of integrating natural compounds into comprehensive post-transplant care, highlighting their potential to enhance graft survival and patient outcomes. By providing an updated and critical overview, this article aims to offer new insights and strategic directions for improving postoperative management in lung transplant recipients through the use of natural bioactive agents.
Abstract from DOAJ. Public domain (CC0 1.0).
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Li, C., Jiang, X., Onyebuchi, I., et al. (2026). Advances in the application of natural compounds in post-lung transplantation management. Transplantation Reports. https://doi.org/10.1016/j.tpr.2026.100208