Tumour-infiltrating adipocyte-derived 12,13-DiHOME subverts CD8 + T cell immunity in pancreatic ductal adenocarcinoma by promoting PPARγ-mediated ferritinophagy and tumour-associated neutrophil ferroptosis

Gut · Published 2026-05-28 · DOI 10.1136/gutjnl-2025-337119

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Authors (23)

Yan Luo, Jiayi Yang, Xinyuan Liu, Binru Zhang, Tianhang Yu, Jian Guan, Yiqin Song, Qiyuan Li, Tianqi Lu, Wei Liu, Linzhu Zou, Yongming Lin, Jiawen Wu, Yuncheng Han, Guanqun Li, Xinlei Yang, Yingmei Zhang, Hongtao Tan, Xuewei Bai, Hua Chen, Jisheng Hu, Rui Kong, Bei Sun

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Publication details

Year

2026

Citation

Luo, Y., Yang, J., Liu, X., et al. (2026). Tumour-infiltrating adipocyte-derived 12,13-DiHOME subverts CD8 + T cell immunity in pancreatic ductal adenocarcinoma by promoting PPARγ-mediated ferritinophagy and tumour-associated neutrophil ferroptosis. Gut. https://doi.org/10.1136/gutjnl-2025-337119

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