Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy

Nature Microbiology · Published 2026-07-30 · DOI 10.1038/s41564-026-02433-0

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Authors (14)

Dylan Kramer, Clarissa Santos Rocha, Christopher A. Gaulke, Marie Nearing, Sumathi Sankaran-Walters, Ikaika Loque, Anugraha Kidigannappa, Eric Pham, Shuang Hu, Patrawin Wanakumjorn, Ramona Abbattista, Abhaya Dandekar, Roland Faller, Satya Dandekar

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Publication details

Year

2026

Citation

Kramer, D., Rocha, C., Gaulke, C., et al. (2026). Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy. Nature Microbiology. https://doi.org/10.1038/s41564-026-02433-0

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