Central European Journal of Sport Sciences and Medicine · Published 2025-01-01 · Journal article · DOI 10.18276/cej.2025.2-04
Physical exercise (PE) has improved brain function by encouraging neuroplasticity via a number of different neurobiological processes. Gama-amino butyric acid (GABA) has potentiality to modify neuroplastic capacity of neurons through trophic action. L-glutamata of the brain naturally produces GABA while focused scientific analysis is now towards its physiological influence towards brain health. Investigation shows very less research between these two factors, and no comprehensive review study so far. The present study based on PRISMA-P, 2015 guidelines accumulated latest information to better understand how physical exercise influences GABA levels in the brain. Using the PRISMA 2020 flow diagram, a rational approach was guaranteed during the screening process for existing literature that meets the criteria. These existing non-randomized controlled trials (Non-RCT) and randomized controlled trials (RCT) have shown that aerobic interventions boost GABA levels in the human brain that has a positive impact. This innate benefit may be considered as a form of medicinal and remedial treatment for depression, anxiety disorders, and in general cognitive health. These results, which are associated with increased GABA exposure and its mechanism, imply that exercise has the potential to be an intervention for enhancing psychological competence or cognitive health, executive function, and sport performance as well.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →