Not your usual drug-induced liver injury: Dolutegravir-associated granulomatous hepatitis

Southern African Journal of HIV Medicine · Published 2026-06-25 · DOI 10.4102/sajhivmed.v27i1.1817

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Authors (6)

Muhammed Vally, Muhammad Ayob, Adam Mahomed, Kairoonisha Mahomed, Washington Mudini, Vikash Lala

Abstract

Dolutegravir is an integrase inhibitor in first-line antiretroviral therapy in South Africa. We describe a patient who developed severe drug-induced liver injury on dolutegravir-containing antiretroviral treatment, in whom liver biopsy demonstrated subacute hepatic necrosis, non-necrotising granulomatous inflammation, and bile duct injury: an uncommon histological pattern in dolutegravir-associated hepatotoxicity.

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Publication details

Year

2026

Citation

Vally, M., Ayob, M., Mahomed, A., et al. (2026). Not your usual drug-induced liver injury: Dolutegravir-associated granulomatous hepatitis. Southern African Journal of HIV Medicine. https://doi.org/10.4102/sajhivmed.v27i1.1817

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