Hypertension in Pregnancy · Published 2026-02-19 · DOI 10.1080/10641955.2026.2633230
Objective Preeclampsia is a significant pregnancy complication associated with abnormal placental formation. Cadherin-11, a cell adhesion molecule, plays a role in trophoblast differentiation and placental development. The aim of this study was to evaluate the relationship between cadherin-11 levels in maternal serum in early second trimester and subsequent development of preeclampsia.Methods In this retrospective nested case–control study, 160 pregnant women (80 preeclampsia, 80 control) who were evaluated and followed up between 15-20 weeks of gestation between 1 March and 1 June 2024 were included. Serum cadherin-11 levels were measured by enzyme-linked immunosorbent assay method. Clinical, biochemical and obstetric data were compared. Diagnostic values were determined by receiver operating characteristic curve and logistic regression analyses.Results Cadherin-11 levels were significantly higher in the preeclampsia group compared to the control group (p < 0.001). This increase was more pronounced in early-onset preeclampsia. According to receiver operating characteristic analysis, area under the curve was 0.880 in the diagnosis of preeclampsia and 0.903 in early-onset preeclampsia. In addition, the mean age of pregnant women in the early-onset preeclampsia group was significantly higher than both the control and late-onset preeclampsia groups.Conclusion Maternal serum cadherin-11 levels may be a significant biomarker for predicting preeclampsia, especially early-onset forms. This finding may provide a new insight for early intervention and prophylactic strategies.
Abstract from DOAJ. Public domain (CC0 1.0).
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