Gut Microbes · Published 2026-05-29 · DOI 10.1080/19490976.2026.2672791
Jingwen Liu, Pu Zhao, Deming Jiang, Shuyan Li, Chaoqiao Jin, Dingting Xu, Xiaoying Wang, Yan Chen, Bufu Tang, Xudong Qu
The gut microbiome functions as a key regulator of tumorigenesis and progression, thereby modulating tumor development and treatment outcomes (including chemoresistance, immunotherapy efficacy, and adverse effects) through its influence on the immune microenvironment and metabolite-mediated signaling pathways. Recent advances in multiomics technologies (metagenomics, metabolomics, and transcriptomics) have generated large-scale, comprehensive, and heterogeneous datasets whose complexity exceeds the capabilities of manual analysis, thus necessitating the implementation of artificial intelligence-based approaches. This review systematically examines the crucial role of the gut microbiome in tumorigenesis, with particular emphasis on colorectal cancer (CRC), specifically addressing its utility as a diagnostic and prognostic biomarker. Furthermore, building upon existing applications of artificial intelligence (AI) in microbiome research and cancer diagnosis and treatment, this review presents an AI-driven precision intervention framework and delineates personalized treatment strategies.
Abstract from DOAJ. Public domain (CC0 1.0).
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Liu, J., Zhao, P., Jiang, D., et al. (2026). Decoding the microbiome: artificial intelligence-targeted gut microenvironment breakthroughs in personalized cancer therapy. Gut Microbes. https://doi.org/10.1080/19490976.2026.2672791