Endocrinology Research and Practice · Published 2026-03-04 · DOI 10.5152/erp.2026.25855
The use of radioactive 131I (Iodine) to treat well-differentiated thyroid carcinomas is a well-established practice. However, in some cases, 131I may be retained in the gallbladder, leading to false-positive results in the detection of thyroid cancer spread. Unexplained radioiodine uptake in the gallbladder can occur, especially in patients with underlying biliary disease or gallbladder abnormalities. It is important to use single photon emission computed tomography (SPECT), computed tomography (CT), SPECT/CT, and ultrasound (US) findings to confirm that this uptake is not related to cancer. Cite this article as: Leporace M, Calabria F, Lanzillotta A. 131I SPECT/CT of abdominal false-positive uptake: radioiodine gallbladder accumulation mimics hepatic metastasis from thyroid carcinoma. Endocrinol Res Pract. Published online March 2, 2026. doi: 10.5152/erp.2026.25855
Abstract from DOAJ. Public domain (CC0 1.0).
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