Case Reports in Dermatology · Published 2026-08-05 · DOI 10.1159/000551718
Hucheng Zhou, Yuan Xia, Xiaohui Zhao, Hui Xu, Yumei Li
Introduction: Cutaneous angiosarcoma (cAS) is a rare and aggressive malignancy of endothelial origin, most commonly affecting the scalp and face in elderly patients. Diagnosis is often challenging due to histological overlap with other vascular or epithelioid tumors. Secondary cAS typically arises following radiotherapy or chronic lymphedema. Case Presentation: We report a rare case of secondary cAS in a 33-year-old woman developing from a congenital giant abdominal hemangioma, without prior radiation or lymphedema. The lesion progressed from erythema to a large non-healing ulcer. Histopathology revealed poorly differentiated vascular tumor cells, confirmed by immunohistochemistry showing positivity for CD31, ERG, and FLI-1. Due to the extensive lesion, surgical excision was not feasible, and only supportive care was provided. Conclusion: This case emphasizes the importance of early recognition and biopsy in atypical vascular lesions. Secondary cAS may arise from pre-existing vascular anomalies even in the absence of classic risk factors, highlighting the need for individualized management.
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Zhou, H., Xia, Y., Zhao, X., et al. (2026). Cutaneous Angiosarcoma Secondary to Giant Hemangioma of the Abdomen in A Young Woman: A Rare Case. Case Reports in Dermatology. https://doi.org/10.1159/000551718