Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics

Clinical Trials · Published 2026-08-04 · DOI 10.1177/17407745261468001

Free full text

Authors (28)

Stef Baas, Lukas Pin, David S. Robertson, Frank Bretz, Hearn Jay Cho, Laura Flight, Rieke van der Graaf, Mackenzie Graham, Peter Jacko, Thomas Jaki, Jonathan Kimmelman, Andrea Manfrin, Richard Milne, Pavel Mozgunov, Philip Pallmann, Tom Parke, Mahesh K. B. Parmar, Vinciane Pirard, Kate Sahan, Jerome Amir Singh, Brian D. M. Tom, John C. Whittaker, Katie Wozniak, David Wright, Haiyan Zheng, Alex John London, Mark Sheehan, Sofía S. Villar

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Baas, S., Pin, L., Robertson, D., et al. (2026). Adaptive versus fixed designs in confirmatory clinical trials: centering the choice on ethics. Clinical Trials. https://doi.org/10.1177/17407745261468001

Related articles

• Covariate adjustment in randomized trials: An overview · Clinical Trials · 2026 · Same journal
• Covariate adjustment in randomized clinical trials: From general theory to practical insights · Clinical Trials · 2026 · Same journal
• Additional crossovers in cluster randomised crossover trials do not always increase statistical power · Clinical Trials · 2026 · Same journal
• Patient notification about pragmatic clinical trials conducted with a waiver of consent: A qualitative study · Clinical Trials · 2025 · Same journal
• A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials · Clinical Trials · 2025 · Same journal
• Shaping the future of clinical trials through strategic foresight · Clinical Trials · 2026 · Same journal
• Bayesian design and analysis of two-arm cluster randomised trials using assurance: Extension to binary outcomes and comparison of Markov chain Monte Carlo and Integrated Nested Laplace Approximations · Clinical Trials · 2026 · Same journal
• Surrogate markers used as efficacy endpoints in NIH-sponsored clinical trials · Clinical Trials · 2026 · Same journal
• Evidence supporting European Medicines Agency drug approvals (2020–2023): A cross-sectional study of trial design and outcomes · Clinical Trials · 2026 · Same journal
• Confirmatory evidence supporting single pivotal trial new drug approvals by the Food and Drug Administration, 2015 through 2023 · Clinical Trials · 2025 · Same journal