Folia Histochemica et Cytobiologica · Published 2026-06-25 · DOI 10.5603/fhc.110856
Jianzhao Ding, Ye Zhang, Qiyan Li, Bin Gong, Rui Yang, Yanli Tang
INTRODUCTION: Periodontitis, a chronic inflammatory disease that severely compromises oral health and is linked to systemic disorders, has attracted increasing research attention. Kangfuxin (KFX), an ethanol extract derived from Periplaneta americana (L.) with documented anti-inflammatory and tissue-regenerative properties, remains unexplored for localized periodontal therapy. This study investigated whether KFX extended-release gel (KFX-ERG) could inhibit the progression of periodontal disease and provide potential support for the treatment of periodontitis. MATERIAL AND METHODS: We selected the optimal concentration from different component ratios of KFX-ERG for subsequent experiments. In vivo, a periodontitis model was established in rats, and pathological changes in periodontal tissue were examined using histological and micro-computed tomography (micro-CT) analyses. RESULTS: Micro-computed tomography revealed that KFX-ERG reduced alveolar bone resorption in experimental periodontitis in rats. Histopathological analysis further revealed markedly reduced inflammatory cell infiltration and concurrently elevated osteoblast density in periodontal tissues of the KFX-ERG group. CONCLUSIONS: This study establishes a theoretical foundation for the therapeutic application of KFX-ERG in mitigating periodontitis progression and demonstrates its significant potential to promote periodontal tissue regeneration, thereby offering promising translational prospects for clinical regenerative periodontal therapy.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →
Ding, J., Zhang, Y., Li, Q., et al. (2026). Fundamental research on the treatment of periodontitis with Kangfuxin (KFX) extended-release gel. Folia Histochemica et Cytobiologica. https://doi.org/10.5603/fhc.110856