Neuroimage Reports · Published 2026-07-31 · DOI 10.1016/j.ynirp.2026.100391
Rodolphe Nenert, Corina Catiul, Pierre LeVan, Aya M. Miften, Jerzy P. Szaflarski, Amy W. Amara
Introduction: Brain physiological pulsations drive glymphatic clearance of neurotoxins from the brain. Neurodegenerative proteinopathies, including Parkinson's disease (PD), have altered glymphatic function. This study compares brain physiological pulsations important for glymphatic clearance in PD and healthy controls (HC). Methods: PD (N = 13) and HC (N = 20) participants were evaluated using magnetic resonance encephalography (MREG), an ultrafast, 3D spherical stack-of-spirals dynamic neuroimaging technique, to assess spectral power and optical flow in cardiovascular, respiratory, and low-frequency vasomotor bands as indirect proxies for glymphatic clearance. Group differences were analyzed with two-sample t-tests, controlling for age and sex. Results: PD participants demonstrated significantly reduced power in the cardiovascular frequency band and reduced optical flow magnitude in the low-frequency vasomotor band in regions important for visual and cognitive processing and sensorimotor function. Conclusion: PD is associated with alterations in physiological pulsations important for glymphatic flow. Glymphatic clearance may represent a potential therapeutic target for neurodegenerative diseases.
Abstract from DOAJ. Public domain (CC0 1.0).
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Nenert, R., Catiul, C., LeVan, P., et al. (2026). Alterations in brain physiological pulsations in Parkinson's disease: a case-control study. Neuroimage Reports. https://doi.org/10.1016/j.ynirp.2026.100391