Archives of Endocrinology and Metabolism · Published 2025-01-01 · Journal article · DOI 10.20945/2359-4292-2026-0022
Abstract Objective: This study aimed to evaluate extracellular vesicles (EVs) in a group of carriers of familial hypercholesterolemia (FH)-related genetic variants compared to those in family members without FH. Subjects and methods: Annexin V-positive EVs (PS+-EVs), cardiomyocyte-derived EVs (CardioEVs), endothelial cell-derived EVs (EEVs), platelet-derived EVs (PEVs) and tissue factor-expressing EVs (TFEVs) were evaluated to compare individuals with FH and genetic variants (n = 16) and non-FH patients without genetic variants (n = 16). Results: Increased numbers of PS+-EVs, CardioEVs, EEVs and TFEVs were observed in the group c arrying genetic variants. Furthermore, patients with FH who did not use statins had higher counts of these same EVs than non-FH patients who did not use statins. These EVs were significantly correlated with low-density lipoprotein cholesterol (LDL-c) levels. Conclusion: The data suggest that EVs are related to FH and that their cellular origins could be related to cardiovascular complications commonly observed in this disease.
Abstract from DOAJ. Public domain (CC0 1.0).
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