Bangladesh Journal of Pharmacology · Published 2026-06-26 · DOI 10.3329/bjp.v21i2.90116
Thanh Sang Vo, Huu Thien Tran, Dai-Hung Ngo
This study aimed to evaluate the hepatoprotective effects of P. pteropoda extract against carbon tetrachloride (CCl4)-induced hepatotoxicity. The extraction condition was due to ethanol 50%, a solid-to-solvent ratio of 1:10, extraction temperature of 60°C, and extraction time of 4 hours. Phytochemical analysis indicated that total polyphenol and flavonoid contents are 76.5 ± 5.2 mg GAE/g DW and 56.8 ± 2.6 mg QE/g DW, respectively. Notably, pretreatment with the extract increased the viability of hepatic cells up to 71.5% at 200 µg/ml. Moreover, oral administration of the extract at 200 mg/kg reduced aspartate transaminase and alanine transaminase elevation levels by 65% and 59% as compared to CCl4 treatment alone. The extract also improved body weight, maintained survival, restored hepatic GSH level, and reduced lipid peroxidation. These findings demonstrate that P. pteropoda exerts hepatoprotective activity against CCl4-induced hepatotoxicity through antioxidant-mediated mechanisms.
Abstract from DOAJ. Public domain (CC0 1.0).
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Vo, T., Tran, H., Ngo, D. (2026). Hepatoprotective effect of Pluchea pteropoda extract against CCl4-induced hepatotoxicity. Bangladesh Journal of Pharmacology. https://doi.org/10.3329/bjp.v21i2.90116