Genome Medicine · Published 2021-12-01 · Available online 26 Jul 2021 · Journal article · DOI 10.1186/s13073-021-00940-9 · PMID: 34311780 · PMC · Cited by 13 (Crossref)
Devabhaktuni Srikrishna, Kris Sachsenmeier
Abstract If each cancer cell produces on average more than one cancer cell, we see a net growth of the tumors and metastases and vice versa. We review recent clinical results for microsatellite stable metastatic colorectal cancer (MSS-mCRC) suggesting immunotherapy combinations with personalized vaccines, checkpoint inhibitors, targeted therapies, multikinase inhibitors, chemotherapies, and radiation that simultaneously slow cancer cell growth rate and enhance T cell killing rate of cancer cells may in future synergize to control the disease.
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Srikrishna, D., Sachsenmeier, K. (2021). We need to bring R0 < 1 to treat cancer too. Genome Medicine. https://doi.org/10.1186/s13073-021-00940-9