Cell proliferation inhibitors and apoptosis promoters

European Journal of Cancer, Supplement · Published 2020-08-01 · DOI 10.1016/j.ejcsup.2019.09.002

Authors being retrieved — see the publisher record. https://doi.org/10.1016/j.ejcsup.2019.09.002

Abstract

Cancer is characterised by uncontrolled proliferation and prolonged cell survival. In some cases, tumour formation is the result from aberrant activity of various cell-cycle regulators leading to chromosome instability or from alteration of the apoptosis pathway. Ovarian cancer is an entity in which cell-cycle alterations are common. P53, a key regulator of checkpoint G1, is frequently altered in high-grade serous ovarian cancer. Targeting cell-cycle regulators will lead to mitotic catastrophe and cell death in these tumours. Promoting apoptosis is another target that is gaining interest in ovarian cancer.In this review, the most relevant evidence of clinical studies in ovarian cancer with compounds targeting cell cycle or promoting apoptosis is summarised.

Abstract from DOAJ. Public domain (CC0 1.0).

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Publication details

Year
2020

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