Indian Journal of Medical and Paediatric Oncology · Published 2026-07-19 · DOI 10.1055/s-0046-1823118
Sonali Thakur, Varun Shukla, Manikandan M. V., Zachariah Chowdhury, Shashikant Patne, Paramita Paul, Ankita Rungta Kapoor, Prashanth Giridhar, Rachita Rungta, Shashank Saini, Arvind Suresh, Bal Krishna Mishra, Anuj Gupta, Bipinesh Sansar, Akhil Kapoor
Prostate carcinoma is considered a heterogeneous disease, often creating challenges for diagnosis and treatment. Tumor heterogeneity within a single patient is rarely assessed using molecular imaging. Furthermore, aggressive variants of prostate cancer have shown resistance to conventional androgen deprivation therapy. In this case report, we present a patient with an aggressive form of metastatic prostatic adenocarcinoma, exhibiting heterogeneity as revealed by prostate-specific membrane antigen and fluorodeoxyglucose positron emission tomography imaging, and treated with an innovative combination of cabazitaxel and carboplatin, resulting in a positive clinical, serological, and radiological response. However, these findings are derived from a single case and should be interpreted as hypothesis-generating.
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Thakur, S., Shukla, V., V., M., et al. (2026). Novel Approach for Aggressive Variant Prostate Carcinoma: A Case Study on Cabazitaxel–Carboplatin Therapy with Molecular Imaging Insights. Indian Journal of Medical and Paediatric Oncology. https://doi.org/10.1055/s-0046-1823118