American Journal of Alzheimer's Disease and Other Dementias · Published 2026-07-01 · DOI 10.1177/15333175261460967
ShuPing Chen, Haoyu Huang, Xiaoyi Xu, Qin Wang, Yingqi Lu, Zesen Zhuang, Wanqing Lin, Qing Zeng, Dan Wang, ShangJie Chen
Background This study aimed to investigate the correlation between multi-metric resting-state fMRI (rs-fMRI) changes and cognitive performance in amnestic mild cognitive impairment (aMCI), moving beyond single-metric analyses. Methods Forty aMCI patients and twenty healthy controls underwent 3.0T rs-fMRI and neurocognitive assessment (MoCA, DST). Multiple rs-fMRI metrics (ReHo, ALFF/fALFF, RSFC) were analyzed for their association with cognition. Results aMCI patients showed increased frontal ReHo, decreased ALFF in default mode network hubs, and reduced prefrontal-parietal-temporal RSFC. Frontal hyper-synchronization correlated negatively with cognitive scores, while DMN ALFF correlated positively. Conclusions Multi-metric fMRI detects characteristic functional alterations in aMCI, indicating regional brain damage or compensatory changes linked to cognitive performance.
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Chen, S., Huang, H., Xu, X., et al. (2026). Multi-Index Brain Function-Cognition Correlation in Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study. American Journal of Alzheimer's Disease and Other Dementias. https://doi.org/10.1177/15333175261460967