Case Reports in Nephrology · Published 2026-01-01 · DOI 10.1155/crin/5476216
Hidradenitis suppurativa (HS) (Verneuil’s disease) is a chronic inflammatory cutaneous disorder with systemic inflammatory potential. A rare and severe sequela of this sustained inflammation is reactive (AA) amyloidosis, typically presenting with nephrotic-range proteinuria and progressive renal failure. Here, we report a 50-year-old male with severe (Hurley Stage III) HS who developed nephrotic syndrome secondary to biopsy-proven renal AA amyloidosis. Initiation of the TNF-α inhibitor adalimumab induced a dramatic concurrent improvement in both cutaneous and renal disease activities. Proteinuria declined from a baseline of 9/24 to 2 g/24 h at 4 months and subsequently to 0.9 g/24 h at 10 months, signifying a near-complete nephrotic remission.
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