The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729–001): a phase 1a/b trial

The Lancet Gastroenterology & Hepatology · Published 2026-05-22 · DOI 10.1016/s2468-1253(26)00058-0

Authors (29)

Man-Fung Yuen, Edward Gane, Jacinta A Holmes, Simone I Strasser, Apinya Leerapun, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Elina Berliba, Alina Jucov, Yoon Jun Kim, Young-Suk Lim, Emily P Thi, Timothy Eley, Kevin R Gray, Elina Medvedeva, Varun Sharma, Christine Espiritu, Sharie C Ganchua, Bhavna S Paratala, Christina Iott, Heather Sevinsky, Tiffany Fortney, Mark Anderson, Gavin A Cloherty, Michael J Sofia, Ganapati Reddy Pamulapati, Amy C H Lee, Gastón Picchio, Karen D Sims

Abstract

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Publication details

Year
2026

Citation

Yuen, M., Gane, E., Holmes, J., et al. (2026). The small interfering RNA imdusiran as single and multiple doses in healthy, randomised individuals and non-randomised individuals with chronic hepatitis B (AB-729–001): a phase 1a/b trial. The Lancet Gastroenterology & Hepatology. https://doi.org/10.1016/s2468-1253(26)00058-0

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