Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis

Journal of Clinical Investigation · Published 2026-08-04 · DOI 10.1172/jci199140

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Authors (23)

Clayton W. Winkler, Benjamin Schwarz, Katie Williams, Sara Alehashemi, Simote T. Foliaki, Joseph Snow, Lisa Joseph, Audrey Thurm, Christopher L. Friend, Gwendolyn Cooper, Eric Bohrnsen, Farzana Bhuyan, Nathan T. Brandes, Ruin Moaddel, Manfred Boehm, Guibin Chen, Cole D. Kimzey, Bibiana Bielekova, Joanna Kocot, Peter Kosa, Cathryn L. Haigh, Raphaela Goldbach-Mansky, Karin E. Peterson

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Publication details

Year

2026

Citation

Winkler, C., Schwarz, B., Williams, K., et al. (2026). Proteasome mutations associated with CANDLE syndrome cause altered neuronal development by dysregulating polyamine synthesis. Journal of Clinical Investigation. https://doi.org/10.1172/jci199140

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