AIDS Research and Therapy · Published 2026-04-06 · DOI 10.1186/s12981-026-00881-6
Abstract Long-acting injectable HIV pre-exposure prophylaxis (PrEP), particularly lenacapavir, has demonstrated near-complete efficacy, yet its public health impact depends on community awareness, knowledge and acceptance. This cross-sectional study assessed awareness, knowledge, perceptions, acceptability, and predictors of lenacapavir use among adults in Ghana. We found awareness, knowledge, and perceptions were generally low, whilst acceptability was moderate (60.5%). Poor perception [(aOR = 0.12, 95% CI (0.05–0.29), p < 0.001)] and irregular exposure to online health information [(aOR = 0.24, 95% CI (0.07–0.77), p = 0.017)] were independently associated, 88.0% and 76.0% respectively, with lower acceptability. Targeted education, health worker engagement, and supportive policies are essential to facilitate lenacapavir uptake in Ghana.
Abstract from DOAJ. Public domain (CC0 1.0).
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