A case of infarcted Warthin tumor misdiagnosed as Warthin-like mucoepidermoid carcinoma: diagnosis confirmed by MAML2 rearrangement with case report and literature review

Frontiers in Oncology · Published 2026-08-03 · DOI 10.3389/fonc.2026.1815098

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Authors (4)

Yalan He, Xin Xia, Shaoce Xu, Chi Zhang

Abstract

Mucoepidermoid carcinoma is a common malignant neoplasm of the parotid gland. A rare pathological subtype, Warthin-like mucoepidermoid carcinoma, closely resembles infarcted Warthin tumor in clinical presentation and histopathological features, and contributes to a high-risk of misdiagnosis. Therefore, extensive experience in morphological diagnosis by pathologists and molecular testing results are crucial for accurate diagnosis. We report a case of infarcted Warthin tumor initially misdiagnosed as Warthin-like mucoepidermoid carcinoma. The diagnosis was subsequently corrected based on molecular testing results, in conjunction with clinical features and multi-institutional pathological consultation. We report this case to raise awareness of this rare entity and to avoid inappropriate clinical management.

Abstract from DOAJ. Public domain (CC0 1.0).

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Publication details

Year
2026

Citation

He, Y., Xia, X., Xu, S., et al. (2026). A case of infarcted Warthin tumor misdiagnosed as Warthin-like mucoepidermoid carcinoma: diagnosis confirmed by MAML2 rearrangement with case report and literature review. Frontiers in Oncology. https://doi.org/10.3389/fonc.2026.1815098

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