International Journal of Medicine and Health Development · Published 2026-07-01 · DOI 10.4103/ijmh.ijmh_144_25
Divya S. Dixit, Apoorva Mishra, Nitin Bhola, Bhushan P. Mundada, Parmarth M. Sonpal
Abstract A rare, benign, and aggressive osteolytic neoplasm of the craniomaxillofacial region, central giant cell granuloma (CGCG) is identified histologically by a large number of uniformly distributed multinucleated giant cells within a sea of spindle-shaped mesenchymal stromal cells, dispersed throughout the fibrovascular connective tissue stroma containing areas of hemorrhage. Improved therapy and prognosis of this locally damaging lesion depend on a prompt diagnostic evaluation and sufficient histopathologic confirmation. A young female patient presented with a rare case of massive destructive CGCG covering the entire left parasymphysis of the jaw, resulting in significant bone resorption and many holes in the buccal, medial, and lingual cortical expansions. After enucleation and vigorous curettage, a peripheral ostectomy that preserved the mandible’s continuity, and taitanium implant plate reconstruction were successfully carried out.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →
Dixit, D., Mishra, A., Bhola, N., et al. (2026). Central Giant Cell Granuloma Unveiled: A Rare Case Report with Strategic Diagnostic and Surgical Interventions. International Journal of Medicine and Health Development. https://doi.org/10.4103/ijmh.ijmh_144_25