Acta Neurochirurgica · Published 2026-06-24 · DOI 10.1007/s00701-026-06967-4
Khushal Gupta, Moneebah Ashraf, Dorsa Farahnak, Elham Rahmanipour, Maryam Alamdar, Clayton Rawson, David Altschul, Mehrdad Pahlevani, Michael Karsy
Abstract Background Visual impairment due to optic chiasm compression is a frequent complication of pituitary macroadenomas and substantially impacts quality of life. Reported postoperative visual field (VF) results after endoscopic endonasal transsphenoidal surgery (EETS) vary across series. We performed a single-arm meta-analysis to quantify postoperative VF outcomes after EETS for pituitary macroadenomas. Method PubMed/MEDLINE, Scopus, and Web of Science were searched in accordance with PRISMA through September 2025. Eligible studies were prospective or retrospective clinical series of pituitary macroadenomas (≥ 5 patients) undergoing EETS with extractable postoperative VF outcomes. Pooled proportions for VF improvement, normalization, stability, deterioration, and cerebrospinal fluid (CSF) leak were calculated using random-effects models with Freeman–Tukey double-arcsine transformation. Heterogeneity was assessed using I2 and prediction intervals were reported. Results Twenty nine studies involving 2,943 patients met criteria. Across studies, the combined rate of postoperative VF improvement was 79% (95% CI: 73–84%), while normalization was achieved in 41% (95% CI: 29–53%). VFs remained unchanged in 19% (95% CI: 14–25%) of patients, and deterioration following surgery was infrequent (1%; 95% CI: 0–1%). The pooled postoperative CSF leak rate was 7% (95% CI: 4–10%). Conclusion In pooled single-arm data, EETS for pituitary macroadenomas is associated with high rates of VF improvement and rare postoperative deterioration. Because VF testing and follow-up were heterogeneous across studies, these pooled results should be interpreted as benchmark outcome rates rather than standardized recovery “patterns.” Standardized VF reporting is needed to enable stronger prognostic and time-course analyses.
Abstract from DOAJ. Public domain (CC0 1.0).
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Gupta, K., Ashraf, M., Farahnak, D., et al. (2026). Improved visual outcomes after endoscopic endonasal transsphenoidal surgery for pituitary macroadenomas: a single-arm meta-analysis. Acta Neurochirurgica. https://doi.org/10.1007/s00701-026-06967-4