Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment

Cancer Immunology Research · Published 2026-06-30 · DOI 10.1158/2326-6066.cir-25-1602

Free full text

Authors (24)

Marika Viatore, Rebecca Polidori, Anna Rita Putignano, Arturo Bonometti, Daoud Rahal, Marialuisa Barbagallo, Lisa Veghini, Greta Donisi, Gianluca Basso, Desirée Giuliano, Sergio Marchini, Marco Erreni, Maria Rita Fumagalli, Fabio Pasqualini, Fabio Grizzi, Paola Spaggiari, Silvia Uccella, S. Bozzarelli, Alessandro Zerbi, Giovanni Luigi Capretti, Vincenzo Corbo, Massimo Locati, Alberto Mantovani, Federica Marchesi

Abstract

PubPorta does not have an abstract for this article yet.

Read the article at the publisher →

Publication details

Year

2026

Citation

Viatore, M., Polidori, R., Putignano, A., et al. (2026). Multinucleated giant cells in human pancreatic cancer are a distinct macrophage population undergoing a DNA damage response and associated with an aggressive tumor microenvironment. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.cir-25-1602

Related articles

• In situ vaccination, low-dose targeted radionuclide therapy, and immune checkpoint inhibition eradicate poorly immunogenic metastatic tumors in murine cancer models · Cancer Immunology Research · 2026 · Same journal
• ATF7ip Inhibits the Tumor Immune Response by Promoting Terminal CD8+ T-cell Exhaustion · Cancer Immunology Research · 2026 · Same journal
• Hypoxia-Induced ADAM8+ Macrophages and FAP+ Fibroblasts Form an Extracellular Matrix–Remodeling Niche at the Tumor Boundary in HCC · Cancer Immunology Research · 2026 · Same journal
• Tumor-Derived Complement C3 Overexpression in STK11 -Mutant Lung Adenocarcinoma Drives Tumor Growth and Immune Checkpoint Inhibitor Resistance · Cancer Immunology Research · 2026 · Same journal
• Automated Computational Flow Cytometry Correlates Decreasing Neutrophil-to-Lymphocyte Ratio to Improved Survival in NSCLC after Immune Checkpoint Blockade · Cancer Immunology Research · 2026 · Same journal
• Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer · Cancer Immunology Research · 2026 · Same journal
• Immune hallmarks of recurrent immune checkpoint inhibitor-mediated inflammatory arthritis · Cancer Immunology Research · 2026 · Same journal
• Low Inflammation Correlates with Protumor Tim4+TREM1+ Resident Macrophage Expansion and Limited Monocyte-Derived Macrophage Differentiation during Peritoneal Colorectal Cancer · Cancer Immunology Research · 2026 · Same journal
• Cancer-Intrinsic Protein Neddylation Modulates the Intratumoral Immune Landscape to Constrain Immune Checkpoint Blockade Therapy · Cancer Immunology Research · 2026 · Same journal
• Enhancement of Ferroptosis in Escape Variant Tumor Cells by IFNγ Derived from Antigen-Specific T Cells Controls Tumor with Heterogeneity · Cancer Immunology Research · 2026 · Same journal