Indian Journal of Pathology and Microbiology · Published 2026-01-01 · DOI 10.4103/ijpm.ijpm_742_24
Ganglioglioma is a glioneuronal tumor comprised of a combination of neoplastic ganglion and glial cells and associated with mutations in the MAPK signaling pathway. It is considered a central nervous system (CNS) World Health Organisation grade 1 tumor and is usually seen in a younger age group, particularly in the first two decades of life. The most common location is the temporal lobe, although they can occur anywhere in the central nervous system. They usually have an excellent prognosis, but around 5% of gangliogliomas are associated with aggressive behavior. Recurrence or malignant transformation in gangliogliomas is rare. We report an unusual case of recurrent aggressive ganglioglioma in a 12-year-old child with unexpected novel genotypic expression along with a brief review of literature.
Abstract from DOAJ. Public domain (CC0 1.0).
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