MARINE DRUGS · Published 2026-07-16 · DOI 10.3390/md24070247
Xuelei Zhang, Yingshu Yu, Kai Liu, Yonghong Liu, Hong Zhang, Jiao Xiao
Four novel alkaloids, including three <i>γ</i>-lactam alkaloids (<b>1</b>–<b>3</b>) and one diketopiperazine (<b>4</b>), along with eight previously known compounds (<b>5</b>–<b>12</b>), were isolated from the marine-derived fungus <i>Aspergillus fumigatus</i> SYPHU504. Their structures, including the tentative stereochemical assignments of the side-chain double bonds in <b>2</b> and <b>3</b>, were elucidated through comprehensive spectroscopic analysis and in comparison with the literature’s data. All isolated compounds were evaluated for their anti-leukaemic activities against human leukaemia cell lines K562 and RS4;11 using the MTT assay. Compounds <b>4</b>, <b>6</b>, <b>7</b>, and <b>9</b>–<b>12</b> exhibited notable cytotoxic activities against both RS4;11 and K562 cell lines, with IC<sub>50</sub> values ranging from 5.02 ± 2.33 to 31.85 ± 0.50 μM. The results of Western blotting and Annexin V-FITC/PI staining elucidated that compounds <b>4</b>, <b>7</b>, and <b>10</b> could induce apoptosis in both RS4;11 cells and K562 cells.
Abstract from DOAJ. Public domain (CC0 1.0).
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Zhang, X., Yu, Y., Liu, K., et al. (2026). Isolation and Characterisation of Alkaloids from Marine-Derived Aspergillus fumigatus SYPHU504 with Antiproliferative Activity. MARINE DRUGS. https://doi.org/10.3390/md24070247