Frontiers in Allergy · Published 2026-07-02 · DOI 10.3389/falgy.2026.1848808
Heather M. Opseth, Michelle Gruver
Over the last decade, the prevalence of IgE-mediated food allergies has increased, alongside therapeutic innovations such as oral immunotherapy (OIT), omalizumab, combination approaches, intranasal epinephrine, and emerging biomarker-guided strategies. This mini review synthesizes evidence published between 2019 and 2025 and evaluates how these advances intersect with persistent safety and clinical decision-making challenges. Although these therapies demonstrate promising efficacy, validated risk-stratification tools capable of guiding individual treatment selection are lacking. The proposed conceptual framework illustrates how patient characteristics, biomarkers, and treatment-specific risks may ultimately support individualized therapeutic decision-making.
Abstract from DOAJ. Public domain (CC0 1.0).
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Opseth, H., Gruver, M. (2026). Bridging innovation and risk: the missing role of validated risk-stratification in IgE-mediated food allergy management. Frontiers in Allergy. https://doi.org/10.3389/falgy.2026.1848808