Journal of Clinical Practice · Published 2026-04-09 · DOI 10.17816/clinpract703530
BACKGROUND: Automated computed tomography (CT) perfusion analysis systems are critical for patient selection for reperfusion therapy in acute ischemic stroke. Systems such as RAPID (iSchemaView/RapidAI, USA) and Olea Sphere (Olea Medical, France) are widely used in clinical practice; however, a validated domestic system for automated CT perfusion processing is lacking in the Russian Federation. Among similar systems that have a registration certificate in the Russian Federation, Vitrea (Canon Medical Systems, USA, Japan) is available in clinical practice. AIM: To validate the Russian system ArchiMed PRO Chronos by comparing it with the Vitrea (Canon Medical Systems, USA, Japan) software for quantitative assessment of ischemic core and critical hypoperfusion area. METHODS: A retrospective study included 52 patients with acute ischemic stroke caused by large vessel occlusion and symptom onset within 24 hours. Correlation between systems was assessed for ischemic core volume and critical hypoperfusion area determination. RESULTS: Strong correlation was found between systems for ischemic core volume (r=0.95) and critical hypoperfusion area (r=0.85). After excluding studies with inadequate segmentation, correlation improved to r=0.98 and r=0.93, respectively. Adequate segmentation was achieved in 84.6% of cases for both systems. No statistically significant differences between systems were detected (p 0.05). CONCLUSION: The ArchiMed PRO Chronos system demonstrated excellent agreement with Vitrea and can be used for quantitative CT perfusion analysis and patient selection for reperfusion therapy.
Abstract from DOAJ. Public domain (CC0 1.0).
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