Human Nutrition & Metabolism · Published 2025-10-30 · DOI 10.1016/j.hnm.2025.200349
There is emerging evidence that the gut-brain axis can be significantly influenced through a gut friendly diet. Indeed, nutritional neuroscience holds a significant role in managing the gut brain axis and mental health disorders as numerous pathways, chiefly, neurological, humoral and immune pathways are involved in the bidirectional communication of gut and brain. Moreover, these pathways are interlinked with the gut microbiota, performing a synergistic effect on gut-brain axis. Consequently, nutrients and gut metabolites have become crucial for managing the gut-brain communication and thereby handling various mental health disorders. Furthermore, the incorporation of dietary interventions through special diets can efficiently contribute to the maintenance of gut-brain health. Apart from this, advanced nutritional therapies, i.e., nutritional psychiatry, microbial biotherapies have been shown promising effects on altered gut brain signalling and health. Nonetheless, the role of nutritional diet in managing the gut brain axis is yet to be discussed in detail. Additionally, there is a growing need to investigate the impact of nutrients on healthy gut-brain communication within the field of nutritional psychiatry. On account of these gaps and findings, this review highlights the importance of diet and nutrition on a healthy gut-brain axis through the mechanism of action of different nutritional compounds, impact of special diets and novel nutritional and psychobiotic influenced strategies.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →