Vaccine: X · Published 2026-05-22 · DOI 10.1016/j.jvacx.2026.100836
Jaime Moreno, Geard Gomez, Olga Sanabria, James Meneses, Adriana Bautista, Carolina Duarte, Nelson Alvis, Alejandro De la Hoz, Fernando de la Hoz
Background: Colombia introduced the PCV7 in 2010, PCV10 in 2012, and PCV13 in 2022. Evidence on long-term pneumococcal serotype dynamics and the potential impact of new PCVs in Colombia remains limited. Methods: We conducted a retrospective analysis using national surveillance data on IPD isolates from children and adults collected between 2005 and 2023. The study period included a pre-vaccine era (2005–2009) and four subsequent periods corresponding to the sequential introduction of PCV7, PCV10, and PCV13. Temporal trends in serotype distribution were assessed using χ2 tests. Theoretical vaccine coverage was estimated for currently licensed PCVs (10, 13, 15, 20, and 21) and for new formulations (PCV24 and PCV25). Results: A total of 7824 IPD isolates were included. Following universal introduction of PCV10, most PCV10 serotypes declined across all age groups. In contrast, serotype 19A increased substantially over the study period, rising from 3% of all isolates in 2005–2009 to 33% in 2023. Non-PCV13 serotypes particularly 6C, 23A , and 15A increased from 22% in 2005–2009 to 46% in 2013–2018. Among children <2 years, PCV21, PCV24, and PCV25 provided approximately 81–87% theoretical coverage of serotypes detected from 2019 to 2023; among adults, coverage ranged from 74% to 78%. Serotype 19A became the predominant antimicrobial-resistant serotype. PCV20–21 and PCV24-PCV25provide substantial coverage of resistant strains. Conclusions: In Colombia, PCV10 introduction was followed by a marked decline in PCV10 serotypes and a substantial increase in serotype 19A and other non-PCV13 serotypes. Continued nationwide surveillance is essential to monitor serotype trends and guide policy decisions regarding the introduction of next-generation PCVs.
Abstract from DOAJ. Public domain (CC0 1.0).
Read the article at the publisher →
Moreno, J., Gomez, G., Sanabria, O., et al. (2026). Long-term evolution of pneumococcal serotypes linked to invasive diseases in Colombia and potential coverage by new pneumococcal vaccines: An analysis of national surveillance data between 2005-2023. Vaccine: X. https://doi.org/10.1016/j.jvacx.2026.100836