Clinical and Applied Thrombosis/Hemostasis · Published 2026-01-01 · DOI 10.1177/10760296251415185
Background Recent advances in the diagnosis and treatment of pulmonary thromboembolism (PTE) have significantly improved survival rates. This progress has shifted greater attention to long-term prognosis, highlighting the need for holistic management that integrates acute care, systematic follow-up, and continuous monitoring. Methods The Optimal Follow-Up in Pulmonary Embolism (OFUPE) is a prospective randomized study comparing two follow-up strategies in acute PTE patients: (1) the optimal follow-up strategy, which comprises a systematic protocol incorporating evidence-based education, individualized care planning, and telemedicine support; and (2) the routine follow-up strategy, consisting of standard monitoring. Eligible patients with acute PTE are randomly assigned in a 1:1 ratio to each group. Primary endpoints include all-cause mortality and adverse events. Discussion The OFUPE study examines the role of holistic management in PTE and proposes a systematic framework for post-PTE care. Trial registration Chinese Clinical Trial Registry ChiCTR2200064675.
Abstract from DOAJ. Public domain (CC0 1.0).
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